ID   VIH_ARMVU               Reviewed;          83 AA.
AC   P83627;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2003, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Vitellogenesis-inhibiting hormone;
DE            Short=VIH;
OS   Armadillidium vulgare (Pillbug) (Pill woodlouse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Peracarida; Isopoda; Oniscidea; Crinocheta;
OC   Armadillidiidae; Armadillidium.
OX   NCBI_TaxID=13347 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE OF 1-70, PROTEIN SEQUENCE OF 1-40 AND 48-83, FUNCTION,
RP   DISULFIDE BONDS, TISSUE SPECIFICITY, AND MASS SPECTROMETRY.
RC   TISSUE=Sinus gland {ECO:0000269|PubMed:10480992};
RX   PubMed=10480992; DOI=10.1006/gcen.1999.7330;
RA   Greve P., Sorokine O., Berges T., Lacombe C., van Dorsselaer A., Martin G.;
RT   "Isolation and amino acid sequence of a peptide with vitellogenesis
RT   inhibiting activity from the terrestrial isopod Armadillidium vulgare
RT   (Crustacea).";
RL   Gen. Comp. Endocrinol. 115:406-414(1999).
RN   [2] {ECO:0000305}
RP   TISSUE SPECIFICITY.
RX   PubMed=12679090; DOI=10.1016/s0016-6480(02)00645-7;
RA   Azzouna A., Philippe M., Jarry T., Greve P., Martin G.;
RT   "Localization of crustacean hyperglycemic and vitellogenesis-inhibiting
RT   hormones in separate cell types in the protocerebrum of the woodlouse
RT   Armadillidium vulgare (Crustacea, Isopoda).";
RL   Gen. Comp. Endocrinol. 131:134-142(2003).
CC   -!- FUNCTION: Inhibits secondary vitellogenesis in females. Has no
CC       hyperglycemic or molt-inhibiting activity.
CC       {ECO:0000269|PubMed:10480992}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Found in the sinus glands of both male and female.
CC       Found also in the brain; the neuroendocrine structures of the
CC       protocerebrum. {ECO:0000269|PubMed:10480992,
CC       ECO:0000269|PubMed:12679090}.
CC   -!- MASS SPECTROMETRY: Mass=9485; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:10480992};
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P83627; -.
DR   SMR; P83627; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; TAS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; TAS:UniProtKB.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   InterPro; IPR001166; Hyperglycemic.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Neuropeptide; Secreted.
FT   CHAIN           1..83
FT                   /note="Vitellogenesis-inhibiting hormone"
FT                   /id="PRO_0000209868"
FT   DISULFID        15..52
FT                   /evidence="ECO:0000269|PubMed:10480992"
FT   DISULFID        32..48
FT                   /evidence="ECO:0000269|PubMed:10480992"
FT   DISULFID        35..61
FT                   /evidence="ECO:0000269|PubMed:10480992"
SQ   SEQUENCE   83 AA;  9491 MW;  BF8C6E70D24CDAE5 CRC64;
     YNIPLGWGRR DMPGCLGVLG NRDLYDDVSR ICSDCQNVFR DKNVESKCRS DCFSTSYFET
     CIMALDLAEK ISDYKLHASI LKE