ID   VIL3_ARATH              Reviewed;         529 AA.
AC   Q5BPT4; A1DW35; O64618; Q84N40;
DT   29-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=VIN3-like protein 3;
DE   AltName: Full=Vernalization5/VIN3-like protein 2;
GN   Name=VIL3; Synonyms=VEL2; OrderedLocusNames=At2g18880; ORFNames=F19F24.8;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=12481096; DOI=10.1104/pp.010207;
RA   Xiao Y.-L., Malik M., Whitelaw C.A., Town C.D.;
RT   "Cloning and sequencing of cDNAs for hypothetical genes from chromosome 2
RT   of Arabidopsis.";
RL   Plant Physiol. 130:2118-2128(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA   Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 18-529, AND INDUCTION BY COLD.
RC   STRAIN=cv. Columbia;
RX   PubMed=17114575; DOI=10.1101/gad.1493306;
RA   Sung S., Schmitz R.J., Amasino R.M.;
RT   "A PHD finger protein involved in both the vernalization and photoperiod
RT   pathways in Arabidopsis.";
RL   Genes Dev. 20:3244-3248(2006).
RN   [6]
RP   INDUCTION BY COLD.
RC   STRAIN=cv. Landsberg erecta;
RX   PubMed=17174094; DOI=10.1016/j.cub.2006.11.052;
RA   Greb T., Mylne J.S., Crevillen P., Geraldo N., An H., Gendall A.R.,
RA   Dean C.;
RT   "The PHD finger protein VRN5 functions in the epigenetic silencing of
RT   Arabidopsis FLC.";
RL   Curr. Biol. 17:73-78(2007).
CC   -!- FUNCTION: Involved in both the vernalization and photoperiod pathways
CC       by regulating gene expression. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with VIN3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Probably DNA-
CC       associated. {ECO:0000250}.
CC   -!- INDUCTION: By cold, especially after vernalization and transfer to warm
CC       temperatures (e.g. 40 days at 4 degrees Celsius followed by 14 days at
CC       22 degrees Celsius). {ECO:0000269|PubMed:17114575,
CC       ECO:0000269|PubMed:17174094}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC09024.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC003673; AAC09024.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002685; AEC06820.1; -; Genomic_DNA.
DR   EMBL; AY262053; AAP22497.1; -; mRNA.
DR   EMBL; AY924744; AAX23819.1; -; mRNA.
DR   EMBL; EF064793; ABL01540.1; -; mRNA.
DR   PIR; T01616; T01616.
DR   RefSeq; NP_179478.4; NM_127444.4.
DR   AlphaFoldDB; Q5BPT4; -.
DR   BioGRID; 1761; 1.
DR   STRING; 3702.AT2G18880.1; -.
DR   iPTMnet; Q5BPT4; -.
DR   PaxDb; Q5BPT4; -.
DR   PRIDE; Q5BPT4; -.
DR   EnsemblPlants; AT2G18880.1; AT2G18880.1; AT2G18880.
DR   GeneID; 816404; -.
DR   Gramene; AT2G18880.1; AT2G18880.1; AT2G18880.
DR   KEGG; ath:AT2G18880; -.
DR   Araport; AT2G18880; -.
DR   TAIR; locus:2044405; AT2G18880.
DR   eggNOG; ENOG502QR8D; Eukaryota.
DR   HOGENOM; CLU_016873_0_0_1; -.
DR   InParanoid; Q5BPT4; -.
DR   OrthoDB; 191691at2759; -.
DR   PhylomeDB; Q5BPT4; -.
DR   PRO; PR:Q5BPT4; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q5BPT4; baseline and differential.
DR   Genevisible; Q5BPT4; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070417; P:cellular response to cold; IEP:UniProtKB.
DR   GO; GO:0040029; P:regulation of gene expression, epigenetic; IEA:InterPro.
DR   GO; GO:0009409; P:response to cold; IEP:UniProtKB.
DR   GO; GO:0010048; P:vernalization response; IEA:InterPro.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR032881; Oberon_PHD.
DR   InterPro; IPR044514; VIN3-like.
DR   PANTHER; PTHR46286; PTHR46286; 2.
DR   Pfam; PF07227; PHD_Oberon; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   PROSITE; PS50853; FN3; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..529
FT                   /note="VIN3-like protein 3"
FT                   /id="PRO_0000422541"
FT   DOMAIN          312..411
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   ZN_FING         137..207
FT                   /note="PHD-type"
FT   REGION          421..529
FT                   /note="VIN3-Interacting Domain (VID)"
FT                   /evidence="ECO:0000250"
FT   MOTIF           97..104
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   MOTIF           214..221
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        200
FT                   /note="N -> S (in Ref. 3; AAP22497)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   529 AA;  59834 MW;  8416483EA99F7153 CRC64;
     MASFHKGAAG DSMGSSKMSF DQRRQLVLKL SKESEREFKE VLKDWSCNEI RELLRAESKK
     DIKYTGLTKD EIITRLFNIV SKKNTRDHEV EEIIPSPKRQ KRDLVTPLAK AKGKGKMYCQ
     NLACQNKLRE EATFCKRCSC CICFKYDDNK DPSLWLTCNS DSQFDGESCG LSCHLNCAFD
     SEKSGLKEDT PSSDIDGCFN CVSCGKTNSK IECLKKQLII ANEERRVGVF CYRILLAHKL
     LKGTKKYIIV SEEVEKAVMH LKNEFGVPIS CLPSKMSRGL VNRLCCAEKV KKHCSSALKE
     LDGLPLPSTI QGSMKIRIES VLATSVTFDI EAEESFSWGD TNHYRMVYRK VSEKHSSKDL
     TRELFSTSSH QRFTVMELTP ATEYWFKIVS FSGVEELSVD EFIVSTKTLQ DEEVAAVLLN
     MSNCNNANKM EKSGSCSFGF EECVNLIRQL ECSGQVKSDF RKKFLTWYCL KATDKEKHVV
     EIFVDTFKDD KEALAKQLID TFSDCITRKH PEIGGGSESA GVSLILLQD