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VILD_DICDI
ID   VILD_DICDI              Reviewed;        1704 AA.
AC   Q8WQ85; P90524; Q54IR2;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   25-MAY-2022, entry version 123.
DE   RecName: Full=Villidin;
GN   Name=vilA; ORFNames=DDB_G0288557;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, AND
RP   DEVELOPMENTAL STAGE.
RC   STRAIN=AX2;
RX   PubMed=12857859; DOI=10.1091/mbc.e02-12-0827;
RA   Gloss A., Rivero F., Khaire N., Mueller R., Loomis W.F., Schleicher M.,
RA   Noegel A.A.;
RT   "Villidin, a novel WD-repeat and villin-related protein from Dictyostelium,
RT   is associated with membranes and the cytoskeleton.";
RL   Mol. Biol. Cell 14:2716-2727(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1444-1704.
RC   STRAIN=AX4;
RA   Loomis W.F., Iranfar N.;
RL   Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a linker between membranes and the actin
CC       cytoskeleton. {ECO:0000269|PubMed:12857859}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12857859};
CC       Peripheral membrane protein {ECO:0000269|PubMed:12857859}. Cytoplasm,
CC       cytoskeleton {ECO:0000269|PubMed:12857859}. Note=Associated with
CC       membranes and the cytoskeleton.
CC   -!- DEVELOPMENTAL STAGE: Present in low amounts during growth and early
CC       aggregation, but increase during development and reach its highest
CC       level at the tipped mound stage (at protein level).
CC       {ECO:0000269|PubMed:12857859}.
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DR   EMBL; AJ427856; CAD20809.1; -; Genomic_DNA.
DR   EMBL; AAFI02000117; EAL63138.1; -; Genomic_DNA.
DR   EMBL; U78754; AAB36957.1; -; mRNA.
DR   RefSeq; XP_636652.1; XM_631560.1.
DR   AlphaFoldDB; Q8WQ85; -.
DR   SMR; Q8WQ85; -.
DR   STRING; 44689.DDB0191538; -.
DR   PaxDb; Q8WQ85; -.
DR   PRIDE; Q8WQ85; -.
DR   EnsemblProtists; EAL63138; EAL63138; DDB_G0288557.
DR   GeneID; 8626698; -.
DR   KEGG; ddi:DDB_G0288557; -.
DR   dictyBase; DDB_G0288557; vilA.
DR   eggNOG; KOG0303; Eukaryota.
DR   eggNOG; KOG0443; Eukaryota.
DR   HOGENOM; CLU_240788_0_0_1; -.
DR   InParanoid; Q8WQ85; -.
DR   OMA; RIFVWAG; -.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   PRO; PR:Q8WQ85; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:dictyBase.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:dictyBase.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IBA:GO_Central.
DR   GO; GO:0051014; P:actin filament severing; IBA:GO_Central.
DR   GO; GO:0008154; P:actin polymerization or depolymerization; IBA:GO_Central.
DR   GO; GO:0051016; P:barbed-end actin filament capping; IBA:GO_Central.
DR   GO; GO:0046956; P:positive phototaxis; IMP:dictyBase.
DR   GO; GO:0051707; P:response to other organism; TAS:dictyBase.
DR   Gene3D; 1.10.950.10; -; 1.
DR   Gene3D; 2.130.10.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.40.20.10; -; 5.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR015048; DUF1899.
DR   InterPro; IPR007123; Gelsolin-like_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR007122; Villin/Gelsolin.
DR   InterPro; IPR003128; Villin_headpiece.
DR   InterPro; IPR036886; Villin_headpiece_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR11977; PTHR11977; 1.
DR   Pfam; PF08953; DUF1899; 1.
DR   Pfam; PF00626; Gelsolin; 4.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF02209; VHP; 1.
DR   Pfam; PF00400; WD40; 1.
DR   PRINTS; PR00597; GELSOLIN.
DR   SMART; SM01166; DUF1899; 1.
DR   SMART; SM00262; GEL; 5.
DR   SMART; SM00233; PH; 3.
DR   SMART; SM00153; VHP; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF47050; SSF47050; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS51089; HP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Cytoskeleton; Membrane; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..1704
FT                   /note="Villidin"
FT                   /id="PRO_0000051331"
FT   REPEAT          82..122
FT                   /note="WD 1"
FT   REPEAT          133..173
FT                   /note="WD 2"
FT   REPEAT          180..221
FT                   /note="WD 3"
FT   REPEAT          225..271
FT                   /note="WD 4"
FT   DOMAIN          459..563
FT                   /note="PH 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          727..828
FT                   /note="PH 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          871..969
FT                   /note="PH 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REPEAT          1025..1119
FT                   /note="Gelsolin-like 1"
FT   REPEAT          1138..1241
FT                   /note="Gelsolin-like 2"
FT   REPEAT          1293..1390
FT                   /note="Gelsolin-like 3"
FT   REPEAT          1404..1494
FT                   /note="Gelsolin-like 4"
FT   REPEAT          1520..1615
FT                   /note="Gelsolin-like 5"
FT   DOMAIN          1641..1704
FT                   /note="HP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00595"
FT   REGION          439..460
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          606..721
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          848..877
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        6
FT                   /note="I -> F (in Ref. 1; CAD20809)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        389
FT                   /note="S -> Y (in Ref. 1; CAD20809)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        500
FT                   /note="Q -> P (in Ref. 1; CAD20809)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        538
FT                   /note="G -> R (in Ref. 1; CAD20809)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        541
FT                   /note="H -> L (in Ref. 1; CAD20809)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        557..559
FT                   /note="SIN -> AIK (in Ref. 1; CAD20809)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1704 AA;  191191 MW;  1B154563964E5234 CRC64;
     MEYKSIEKSI VRESKVRNVF SKVCKKELFY TNLKVNSASE ELLKSSKSLF AYPSSIGGGS
     CLSITKLSNH GKVPDTPFCI KGHTDPISCF EFSNFNDYVI ATGSRDCTIK IWEVPEEGLI
     KDNLVTPLIT LPKQQKRVTG VYFHPSVDSL FMSSTLDYTL DIWDLSSTGE QSSVIQKLTG
     HEDLIMSVGW NTWSGGDKLA TSSRDKKMRL YDPRSQSTPI QTISTHEGAQ GFKLCWADSN
     GLELICTVGA NKSAQRQLYL WDPRQLQSSQ PLVSKDVTTD SSILSPYYDF GTNMVYLGGK
     GDGIYYYEIE KNNAHHIGKA TFGNVTQSAI TLLPKSVVDV NICEIDRFLR LTAANSVEMV
     SFMCPRKSQL FQEDIFPPCP SGDPTTDCSL WFADKQLKVI PHTISMKPDG VQSIYEVSEE
     EGGKSKEKDK LEQLSKLSIG NSGSGGGGGD GDGNGGDSPF ITEGIVKQEI EGWLFNSYEN
     RYLKIVKDKI YCFLNEDSAQ AIWDSPVLNI KYVDIYDEDE NTSGEEWSLR FNIILLNGKE
     HRMECSTVKQ RDAWCQSINA YREMKQQVDQ SVVSPTMGEF HLVNTTPVAP SPMVISENKN
     ALQKFSVPSP KEQQQQQQQG SESPNSTTPK SSTPTQTRHH SVLSRNPSYT SLKSSGGFSK
     PSPSSSTSTP PSTFASPLSI AQTSSTTTTT TTTTTTTSSS STPPPLRANN STSSTPLNSS
     TGIKQSDIVI EGNLTELIPG LLWNSNTEKW YVVSEGMLYS YKNKSLKQLD PLETIHLEKA
     ISAHKTKEIF TIQGFSFQLS TPNRIIHLLA KTKEERGSWL SVLRQNLKSS GETKPKSVLT
     RASTMDELIS SPMSDDESNT NEGGVEEEEE EQPLEGQLSR KLPGIFSMWG QCFVALLAED
     LFVSRNKLST TPELRIQLSS ISLIKKISPN EFTLYDSMNQ VVCNFRTIAP TAEFDDCTRW
     IDGLEAARKR SIDIIKMFGI NEKEVLSPLP SSSSIPSSGS NGNLLDPSAD DLTRYLDLTA
     IKNGKQKILI QVKGKRKIRV RMVKLSTSSL NCHNSFILDA GPRIFVWAGS KTSRVNKAKA
     LDFANRIRTK ERGGKSTLIQ LDQGRDEQSF DFWEILGGNS SDPIATTPTP EEQDTESIKT
     TIYRVGLDVK KNSLRARLAW EGTDWKLPNK EILNTKFVYV VDCVTEIFVW VGKESSSIQR
     KMATKVALVL QAQKDRVDWT KITRLTEFGE NNLFKEKFAN YPGMLPISTT RQEIKSHVAT
     SKVEHKIETL ASRMTTPFID NEALFTIPID EGGRVKVWKI EDYEKIDHPQ HLYSQFFSSD
     SYIVLYTYMQ NNKEAHVIYY YLGRDSSINE KGTSAYLTVD LNESLVGACV QTRVVANKEC
     KNFLNLFKTK MVIHKGKYNN YDPKKPSLYQ VKGLDKIDIR AVQVEFSSSM LNTLHVSILR
     TPEKIYIWHG KFSLDAEQNS ALSIAENFNS TSAPIEILKE GSESNEFWSA FESTGGRQKY
     FNDIMIQSSS IPTSFTYKPR FFVCSNASGI VEVTEESPFS QDDLDIGSVC ILDVQSHIYL
     WIGSRATHRT KRASMEVVLN FIETSKLGHS KEHTKVLIAT PFEEPIGFKS YFRAWCTSKY
     PKNKLPLVEK DGIPVEQVLK DYLKEIYTYE ELLADPLPAG VDSTKLDTYL NDEDFEKVFK
     MTRTEWLKIP AWKREGIKKE LFLF
 
 
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