VIMB_CARAU
ID VIMB_CARAU Reviewed; 450 AA.
AC P48673;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Vimentin beta;
OS Carassius auratus (Goldfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Carassius.
OX NCBI_TaxID=7957;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Retina;
RX PubMed=8035174; DOI=10.1046/j.1471-4159.1994.63020470.x;
RA Glasgow E., Druger R.K., Fuchs C., Levine E.M., Giordano S., Schechter N.;
RT "Cloning of multiple forms of goldfish vimentin: differential expression in
RT CNS.";
RL J. Neurochem. 63:470-481(1994).
CC -!- FUNCTION: Vimentins are class-III intermediate filaments found in
CC various non-epithelial cells, especially mesenchymal cells. Vimentin is
CC attached to the nucleus, endoplasmic reticulum, and mitochondria,
CC either laterally or terminally.
CC -!- SUBUNIT: Homomer. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in low amounts in retina, optic nerve,
CC brain, and spinal cord and in very high amounts in eye lens.
CC -!- PTM: One of the most prominent phosphoproteins in various cells of
CC mesenchymal origin. Phosphorylation is enhanced during cell division,
CC at which time vimentin filaments are significantly reorganized (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; L23841; AAA21757.1; -; mRNA.
DR PIR; I50484; I50484.
DR AlphaFoldDB; P48673; -.
DR SMR; P48673; -.
DR PRIDE; P48673; -.
DR Proteomes; UP000515129; Genome assembly.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR InterPro; IPR027699; Vimentin.
DR PANTHER; PTHR45652:SF5; PTHR45652:SF5; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Intermediate filament; Reference proteome.
FT CHAIN 1..450
FT /note="Vimentin beta"
FT /id="PRO_0000063766"
FT DOMAIN 89..397
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..81
FT /note="Head"
FT REGION 24..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..117
FT /note="Coil 1A"
FT REGION 118..139
FT /note="Linker 1"
FT REGION 140..231
FT /note="Coil 1B"
FT REGION 232..254
FT /note="Linker 12"
FT REGION 255..393
FT /note="Coil 2"
FT REGION 394..450
FT /note="Tail"
SQ SEQUENCE 450 AA; 52139 MW; D5CCF229AC9011EE CRC64;
MSSRTSTSSY KRMFGAERQA MVRSTYSSRQ YSSPGRTTSR VSYSSASSTS PSLYMSKSAR
SATRLATETL DFGLADAINT EFKANRTNEK AEMQHVNDRF ASYIEEVRFL EQQNKILTAE
LEQMRGKGSS RVGDLYEDEM RELRRQVDQL INEKASVEVD RDNLGENIER LRQKLQEEML
QREDAENSLR SFRQDVDNAS LARLDLERKV ESLQEEIAFL KKLHDEELAE LQMQIQERHV
QIDMEVAKPD LTAALRDVRQ QYETLASRNL QESEEWYKSK FADLSEAATR NSEAVRLAKH
EANDYRRQLQ SLTCDLEALR GTNGSLERQM REMEDNFSIE ASGYQDTIVR LEDDIRNTKD
EMARHLREYQ NLLNVKMALD IEIATYRNLL EGEEYRITTP FPNLSSLSLR ESMKEIRPAM
DSLSKKVVIK TIETRDGHII NQSTQKDNLE