VIMP2_USTMA
ID VIMP2_USTMA Reviewed; 335 AA.
AC A0A0D1CVX2;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2015, sequence version 1.
DT 03-AUG-2022, entry version 20.
DE RecName: Full=Virulence-associated membrane protein 2 {ECO:0000303|PubMed:34093627};
DE Short=VMP2 {ECO:0000303|PubMed:34093627};
DE Flags: Precursor;
GN Name=VMP2 {ECO:0000303|PubMed:34093627};
GN ORFNames=UMAG_01689 {ECO:0000312|EMBL:KIS70518.1};
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631 {ECO:0000312|Proteomes:UP000000561};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021 {ECO:0000312|Proteomes:UP000000561};
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2] {ECO:0000312|Proteomes:UP000000561}
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021 {ECO:0000312|Proteomes:UP000000561};
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RC STRAIN=SG200 {ECO:0000303|PubMed:34093627};
RX PubMed=34093627; DOI=10.3389/fpls.2021.669835;
RA Weiland P., Altegoer F.;
RT "Identification and Characterization of Two Transmembrane Proteins Required
RT for Virulence of Ustilago maydis.";
RL Front. Plant Sci. 12:669835-669835(2021).
CC -!- FUNCTION: During infection, may play a role in establishing and
CC maintaining biotrophy; the formation of a tight interaction zone
CC between the host and the pathogen. {ECO:0000269|PubMed:34093627}.
CC -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:34093627}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:34093627}; Single-
CC pass membrane protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Decreases virulence in Zea mays.
CC {ECO:0000269|PubMed:34093627}.
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DR EMBL; CM003142; KIS70518.1; -; Genomic_DNA.
DR RefSeq; XP_011387666.1; XM_011389364.1.
DR EnsemblFungi; KIS70518; KIS70518; UMAG_01689.
DR GeneID; 23562612; -.
DR KEGG; uma:UMAG_01689; -.
DR VEuPathDB; FungiDB:UMAG_01689; -.
DR eggNOG; ENOG502RDQZ; Eukaryota.
DR OrthoDB; 1557340at2759; -.
DR Proteomes; UP000000561; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IDA:UniProtKB.
DR GO; GO:0051701; P:biological process involved in interaction with host; IMP:UniProtKB.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix;
KW Virulence.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..335
FT /note="Virulence-associated membrane protein 2"
FT /evidence="ECO:0000255"
FT /id="PRO_5002244463"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 33..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..335
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 335 AA; 33723 MW; ED7412CAD54C6B49 CRC64;
MAAGKRRVAS LVLLMIIWWS IVSAAESQCE ERNDYSRKRP SHKPFTSHQN KQDRSCSSPL
PSESCSTSAI TPSDSAVRDT SLSRRGLPGM PGDIEWMGFY GSLLAVPTML SILGIITNYN
LGKSYYNSEL NAQYYKQSRE MLRAHTAKLI QDQEKKFANA GVSWNGMVYG KDGQVNPGAK
LPEWNGRVLG GTVANPKSQP VPGSGGAVQG AAAGVGGGTT AGVAAGAGAA SAGTGPAQVG
GATAGGAGAE AQTGTGAIAT GTGTGGAGDA GGSAPVSSGA EQGDAEAGDE ARGSEERGDD
GTEDRRGGQS EGDDDSDSDG NDEGDAGDAG DAGDA