ID   VINC_BRUMA              Reviewed;         993 AA.
AC   Q17162;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Vinculin;
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Dissanayake S.;
RL   Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in cell adhesion. May be involved in the attachment
CC       of the actin-based microfilaments to the plasma membrane.
CC       {ECO:0000250|UniProtKB:P12003}.
CC   -!- SUBUNIT: Exhibits self-association properties.
CC       {ECO:0000250|UniProtKB:P12003}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:P85972}. Cell junction, adherens junction
CC       {ECO:0000250|UniProtKB:P12003}. Cell membrane
CC       {ECO:0000250|UniProtKB:P12003}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P12003}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:P12003}. Cell junction
CC       {ECO:0000250|UniProtKB:P12003}. Note=Cytoplasmic face of adhesion
CC       plaques. {ECO:0000250|UniProtKB:P12003}.
CC   -!- SIMILARITY: Belongs to the vinculin/alpha-catenin family.
CC       {ECO:0000305}.
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DR   EMBL; U07023; AAB96842.1; -; mRNA.
DR   AlphaFoldDB; Q17162; -.
DR   SMR; Q17162; -.
DR   STRING; 6279.Q17162; -.
DR   Proteomes; UP000006672; Unassembled WGS sequence.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR   InterPro; IPR017997; Vinculin.
DR   InterPro; IPR006077; Vinculin/catenin.
DR   PANTHER; PTHR46180; PTHR46180; 2.
DR   Pfam; PF01044; Vinculin; 1.
DR   SUPFAM; SSF47220; SSF47220; 6.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cell adhesion; Cell junction; Cell membrane; Cytoplasm;
KW   Cytoskeleton; Membrane; Reference proteome; Repeat.
FT   CHAIN           1..993
FT                   /note="Vinculin"
FT                   /id="PRO_0000064257"
FT   REPEAT          258..364
FT                   /note="1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          373..480
FT                   /note="2"
FT                   /evidence="ECO:0000255"
FT   REGION          258..480
FT                   /note="2 X repeats"
FT                   /evidence="ECO:0000255"
FT   REGION          730..797
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        768..788
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   993 AA;  110188 MW;  318CB75FA33E4E2A CRC64;
     MPVFHTKTIE GILEPVAQQV SRLVILHEEA EDGNAVLDLT LPVGAVSRAV DNLIKVGYDT
     CHSSDDRILQ ADMPPALQRV EASSRLLEDA CHMLRADPYS SVARKKLIEG ARGILQGTSA
     LLLSFDESEV RKIIRGCRKV LDYLAVAEVI ESMDDLAQFV KDISPWLTRV SRNIDAREKE
     LTHQVHREIL LRCMDTVKTL SPIMICAMKI FIQITEESQR GQQEAAENRN YLAQRMTDEM
     NEIIRVLQLT TYDEDEWDSD NVTVMRKALS AAQSLLTSAL DWLADSRGRA GATGEKAIRR
     IVDYSERIAA RALPEDARLI RATVSDITSM TDSLCELRNQ GGDSQGLASG CANRLKELVG
     TKEISGILPS ALTNTQRTGG THPAHTVTGR LEQALRWMDN PGVDDNGLGL QAVKAMTSEA
     GNLQPIYSHL QNVRKFVDLC VEIDRQADQL ADLEHRGLGN PPAAHAIRNQ LRNKLRELVD
     IMKKVITDRV VEDFADISTP LKQFVDAVYA SPTIVNRELS FEEKAHNLDD HSSRCANTAL
     LVAKCGPCKN KKTVEAIIEA ANQVNAMTPQ VIKAGKIRLH NDSDSANLHF DNLRREYSDV
     LNRLRSHVDD AIDTSDFIRA SEQAMRQYTV YCENAIRNNE PQQMVDNTSQ IARFGNRVLM
     TAKNEADNSE EPSFVHRVNN AARRLHSAIP PMVNQAKQVA LNPRHGGNAQ SWRDANEHLL
     SAVRQVGDAI TGAGGSRPPS QNLLVESVPP KAPTSPIVHD RIYIREDIPT PPRPPPPVEI
     SPPPRPPPPP ETDDEEETRA FWERYPLLGA SSQPILSAAH NLHQELRQWS SHENEIVAAA
     KRMAILMARL SQLVRGEGGT KKDLVDCAKA IADSSEEVTR LAVQLARQCT VIKMRMTLLQ
     VCERIPTIAT QLKILSTVKA TMLGSQATIG PYGQPIDGSE EDEEAMQQLV LNAQNLMQSV
     KDTVRAAEAA SIKIRTNSGL RLRWIRKPMW SNF