ID   VINT_BPMD2              Reviewed;         356 AA.
AC   Q38361;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 2.
DT   02-DEC-2020, entry version 91.
DE   RecName: Full=Integrase;
DE            EC=2.7.7.- {ECO:0000250|UniProtKB:P03700};
DE            EC=3.1.-.- {ECO:0000250|UniProtKB:P03700};
GN   Name=33; Synonyms=int;
OS   Mycobacterium phage D29 (Mycobacteriophage D29).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Fromanvirus.
OX   NCBI_TaxID=28369;
OH   NCBI_TaxID=1763; Mycobacterium.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suissa M., Wyse J., Bar-On T., Kuhn J.;
RT   "DNA sequence and analysis of the mycrobacteriophage D29 origin and its
RT   integrase-like protein.";
RL   Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9274023; DOI=10.1099/00221287-143-8-2701;
RA   Ribeiro G., Viveiros M., David H.L., Costa J.V.;
RT   "Mycobacteriophage D29 contains an integration system similar to that of
RT   the temperate mycobacteriophage L5.";
RL   Microbiology 143:2701-2708(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9636706; DOI=10.1006/jmbi.1997.1610;
RA   Ford M.E., Sarkis G.J., Belanger A.E., Hendrix R.W., Hatfull G.F.;
RT   "Genome structure of mycobacteriophage D29: implications for phage
RT   evolution.";
RL   J. Mol. Biol. 279:143-164(1998).
CC   -!- FUNCTION: Integrase is necessary for integration of the phage into the
CC       host genome by site-specific recombination.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB69102.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAA49810.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X70352; CAA49810.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U81553; AAB69102.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AF022214; AAC18476.1; -; Genomic_DNA.
DR   PIR; H72803; H72803.
DR   RefSeq; NP_046850.1; NC_001900.1.
DR   SMR; Q38361; -.
DR   GeneID; 1261563; -.
DR   KEGG; vg:1261563; -.
DR   Proteomes; UP000002131; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; DNA-binding; Hydrolase;
KW   Reference proteome; Transferase; Viral genome integration;
KW   Virus entry into host cell.
FT   CHAIN           1..356
FT                   /note="Integrase"
FT                   /id="PRO_0000197503"
FT   DOMAIN          57..135
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          155..346
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        229
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        298
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        301
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        324
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        333
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   356 AA;  39999 MW;  C233337FA9A5C722 CRC64;
     MQASYVSPID GQRYFGPRNY DNRMDAEAWL ASEKRLIDNE EWTPPAEREK KAAASAITVE
     EYTKKWIAER DLAGGTKDLY STHARKRIYP VLGDTPVAEM TPALVRAWWA GMGKQYPTAR
     RHAYNVLRAV MNTAVEDKLV SENPCRIEQK APAERDVEAL TPEELDVVAG EVFEHYRVAV
     YILAWTSLRF GELIEIRRKD IVDDGETMKL RVRRGAARVG EKIVVGNTKT VRSKRPVTVP
     PHVAAMIREH MADRTKMNKG PEALLVTTTR GQRLSKSAFT RSLKKGYAKI GRPDLRIHDL
     RAVGATLAAQ AGATTKELMV RLGHTTPRMA MKYQMASAAR DEEIARRMSE LAGITP