ID   VINT_BPP22              Reviewed;         387 AA.
AC   P04890; Q7PCH4;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   23-FEB-2022, entry version 101.
DE   RecName: Full=Integrase;
DE            EC=2.7.7.- {ECO:0000250|UniProtKB:P03700};
DE            EC=3.1.-.- {ECO:0000250|UniProtKB:P03700};
GN   Name=int;
OS   Salmonella phage P22 (Bacteriophage P22).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Podoviridae; Lederbergvirus.
OX   NCBI_TaxID=10754;
OH   NCBI_TaxID=90371; Salmonella typhimurium.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3491212; DOI=10.1016/0022-2836(86)90491-2;
RA   Leong J.M., Nunes-Dueby S.E., Oser A.B., Lesser C.F., Youderian P.,
RA   Susskind M.M., Landy A.;
RT   "Structural and regulatory divergence among site-specific recombination
RT   genes of lambdoid phage.";
RL   J. Mol. Biol. 189:603-616(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11053393; DOI=10.1128/jb.182.22.6472-6481.2000;
RA   Vander Byl C.S., Kropinski A.M.B.;
RT   "Sequence of the genome of Salmonella bacteriophage P22.";
RL   J. Bacteriol. 182:6472-6481(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12562822; DOI=10.1128/jb.185.4.1475-1477.2003;
RA   Pedulla M.L., Ford M.E., Karthikeyan T., Houtz J.M., Hendrix R.W.,
RA   Hatfull G.F., Poteete A.R., Gilcrease E.B., Winn-Stapley D.A.,
RA   Casjens S.R.;
RT   "Corrected sequence of the bacteriophage P22 genome.";
RL   J. Bacteriol. 185:1475-1477(2003).
CC   -!- FUNCTION: Integrase is necessary for integration of the phage into the
CC       host genome by site-specific recombination. In conjunction with
CC       excisionase, integrase is also necessary for excision of the prophage
CC       from the host genome.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
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DR   EMBL; X04052; CAA27685.1; -; Genomic_DNA.
DR   EMBL; AF217253; AAF75002.1; -; Genomic_DNA.
DR   EMBL; BK000583; DAA00998.1; -; Genomic_DNA.
DR   PIR; C24253; RSBPIP.
DR   RefSeq; NP_059584.1; NC_002371.2.
DR   SMR; P04890; -.
DR   PRIDE; P04890; -.
DR   GeneID; 1262851; -.
DR   KEGG; vg:1262851; -.
DR   Proteomes; UP000001795; Genome.
DR   Proteomes; UP000007960; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; DNA-binding; Hydrolase;
KW   Reference proteome; Transferase; Viral genome integration;
KW   Virus entry into host cell.
FT   CHAIN           1..387
FT                   /note="Integrase"
FT                   /id="PRO_0000197521"
FT   DOMAIN          57..161
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          181..362
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        215
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        242
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        314
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        317
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        340
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        349
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   387 AA;  44783 MW;  5E4EBA51B3B30802 CRC64;
     MSLFRRGETW YASFTLPNGK RFKQSLGTKD KRQATELHDK LKAEAWRVSK LGETPDMTFE
     GACVRWLEEK AHKKSLDDDK SRIGFWLQHF AGMQLKDITE TKIYSAIQKI TNRRHEENWK
     LMDEACRKNG KQPPVFKPKP AAVATKATHL SFIKALLRAA EREWKMLDKA PIIKVPQPKN
     KRIRWLEPHE AKRLIDECQE PLKSVVEFAL STGLRRSNII NLEWQQIDMQ RKVAWIHPEQ
     SKSNHAIGVA LNDTACRVLK KQIGNHHKWV FVYKESSTKP DGTKSPVVRK MRYDANTAWR
     AALKRAGIED FRFHDLRHTW ASWLVQAGVP ISVLQEMGGW ESIEMVRRYA HLAPNHLTEH
     ARQIDSIFGT SVPNMSHSKN KEGTNNT