ID   VINT_FRG3G              Reviewed;         275 AA.
AC   P29164; Q6GZV9;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   02-JUN-2021, entry version 52.
DE   RecName: Full=Integrase homolog;
GN   Name=INT;
OS   Frog virus 3 (isolate Goorha) (FV-3).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Iridoviridae; Alphairidovirinae; Ranavirus.
OX   NCBI_TaxID=654924;
OH   NCBI_TaxID=30343; Dryophytes versicolor (chameleon treefrog).
OH   NCBI_TaxID=8404; Lithobates pipiens (Northern leopard frog) (Rana pipiens).
OH   NCBI_TaxID=45438; Lithobates sylvaticus (Wood frog) (Rana sylvatica).
OH   NCBI_TaxID=8316; Notophthalmus viridescens (Eastern newt) (Triturus viridescens).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1733108; DOI=10.1016/0042-6822(92)90036-o;
RA   Rohozinski J., Goorha R.;
RT   "A frog virus 3 gene codes for a protein containing the motif
RT   characteristic of the INT family of integrases.";
RL   Virology 186:693-700(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15165820; DOI=10.1016/j.virol.2004.02.019;
RA   Tan W.G., Barkman T.J., Gregory Chinchar V., Essani K.;
RT   "Comparative genomic analyses of frog virus 3, type species of the genus
RT   Ranavirus (family Iridoviridae).";
RL   Virology 323:70-84(2004).
CC   -!- FUNCTION: Integrase-recombinase proteins are responsible for catalyzing
CC       strand exchange between DNA molecules and play an important role in the
CC       DNA replication.
CC   -!- FUNCTION: May be required for the formation of concatameric complex
CC       replicative intermediates and/or their resolution before encapsidation.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
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DR   EMBL; M80548; AAA73142.1; -; Genomic_DNA.
DR   EMBL; AY548484; AAT09675.1; -; Genomic_DNA.
DR   PIR; A40823; RSXFF3.
DR   RefSeq; YP_031594.1; NC_005946.1.
DR   GeneID; 2947736; -.
DR   KEGG; vg:2947736; -.
DR   Proteomes; UP000008770; Genome.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; Reference proteome;
KW   Viral genome integration; Virus entry into host cell.
FT   CHAIN           1..275
FT                   /note="Integrase homolog"
FT                   /id="PRO_0000197528"
FT   REGION          88..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..106
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   275 AA;  29944 MW;  1DE5020EF342DF7C CRC64;
     MLLHLILILK SFLPKRNLAF RYDIVALSLT RKILLKHQPP ENVFAALYID SLHGGRHQIM
     PGFCKLSCPT LDVGPGLGRF AASHFSERVS QDRQAQGRER RSVLLPQERR GSSGRQPLYS
     LLPHRPKREG VIGAALCYTS ASHSLSPAAL LPPVGRGKDR RCGRQVGAAG LLRHVGRRRQ
     FAQLTRGPLG LPCALLEPLP LDPHLLDKGR DVGVGGCHDH QGQEDGLLLH GGPEPVLGPQ
     GVIGPAYGRP HANVHALRHE LQHGPLGDPP RLRSG