ID   VIP2_NICBE              Reviewed;         603 AA.
AC   Q52JK6;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Probable NOT transcription complex subunit VIP2;
DE   AltName: Full=Protein VIRE2 INTERACTING PROTEIN2;
DE            Short=NbVIP2;
DE   Flags: Fragment;
GN   Name=VIP2;
OS   Nicotiana benthamiana.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4100;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE, INTERACTION
RP   WITH AGROBACTERIUM VIRE2, AND INDUCTION BY AGROBACTERIUM.
RX   PubMed=17496122; DOI=10.1105/tpc.106.042903;
RA   Anand A., Krichevsky A., Schornack S., Lahaye T., Tzfira T., Tang Y.,
RA   Citovsky V., Mysore K.S.;
RT   "Arabidopsis VIRE2 INTERACTING PROTEIN2 is required for Agrobacterium T-DNA
RT   integration in plants.";
RL   Plant Cell 19:1695-1708(2007).
CC   -!- FUNCTION: Transcriptional regulator required for Agrobacterium-mediated
CC       stable genetic transformation by T-DNA integration in host genome, but
CC       not for T-DNA transient expression. {ECO:0000269|PubMed:17496122}.
CC   -!- SUBUNIT: Binds to VIP1 (By similarity). Interacts with Agrobacterium
CC       tumefaciens VirE2. Forms a complex made of Agrobacterium VirE2, VIP1,
CC       VIP2 and single-stranded DNA (ssDNA). {ECO:0000250,
CC       ECO:0000269|PubMed:17496122}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- INDUCTION: Upon infection with a T-DNA transfer-competent Agrobacterium
CC       strain. {ECO:0000269|PubMed:17496122}.
CC   -!- DISRUPTION PHENOTYPE: Impaired stable genetic transformation by
CC       Agrobacterium T-DNA. {ECO:0000269|PubMed:17496122}.
CC   -!- SIMILARITY: Belongs to the CNOT2/3/5 family. {ECO:0000305}.
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DR   EMBL; DQ000202; AAY15746.1; -; mRNA.
DR   AlphaFoldDB; Q52JK6; -.
DR   SMR; Q52JK6; -.
DR   PRIDE; Q52JK6; -.
DR   GO; GO:0030015; C:CCR4-NOT core complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0015074; P:DNA integration; IMP:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   Gene3D; 2.30.30.1020; -; 1.
DR   InterPro; IPR038635; CCR4-NOT_su2/3/5_N_sf.
DR   InterPro; IPR040168; Not2/3/5.
DR   InterPro; IPR007282; NOT2/3/5_C.
DR   PANTHER; PTHR23326; PTHR23326; 1.
DR   Pfam; PF04153; NOT2_3_5; 1.
PE   1: Evidence at protein level;
KW   Crown gall tumor; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           <1..603
FT                   /note="Probable NOT transcription complex subunit VIP2"
FT                   /id="PRO_0000405595"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          212..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          306..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          355..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   603 AA;  64702 MW;  6A11D4813E8BD84D CRC64;
     MQGTLTSRNT AINNVPSSGV QQSGNNLSGG RFVPNNLPSA LSQIPQGNSH GHSGMTSRGG
     TSVVGNPGYS SNTNGVGGSI PGILPTFAAI GNRSSVPGLG VSPILGNAGP RMTNSVGNIV
     GGGNIGRSIS SGAGLSVPGL ASRLNMNANS GSGNLNVQGP NRLMSGVLQQ ASPQVLSMLG
     NSYPAGGPLS QNHVQAIGNF NSMGLLNDVN SNDGSPFDIN DFPQLSSRPS SAGGPQGQLG
     SLRKQGLSPI VQQNQEFSIQ NEDFPALPGF KGGNADYAMD PHQKEQLHDN TLSMMQQQHF
     SMGRSAGFNL GGTYSSNRPQ QQLQHAPSVS SGGVSFSNIN NQDLLSLHGS DVFQSSHSSY
     QQQGGGPPGI GLRPLNSSGT VSGIGSYDQL IQQYQQHQGQ SQFRLQQMST LGQPFRDQSL
     KSMQSQVAPD PFGMLGLLSV IRMSDPDLTS LALGIDLTTL GLNLNSAENL YKTFGSPWSD
     EPAKGDPEFT VPQCYYAKQP PPLNQAYFSK FQLDTLFYIF YSMPKDEAQL YAANELYNRG
     WFYHREHRLW FMRVANMEPL VKTNAYERGS YICFDPNTWE TIHKDNFVLH CEMLEKRPVL
     PQH