VIPA_SALTI
ID VIPA_SALTI Reviewed; 425 AA.
AC Q04972;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Vi polysaccharide biosynthesis protein VipA/TviB;
DE EC=1.1.1.-;
GN Name=vipA; Synonyms=tviB; OrderedLocusNames=STY4661, t4352;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=8248629; DOI=10.1016/0923-2508(93)90193-6;
RA Waxin H., Virlogeux I., Kolyva S., Popoff M.Y.;
RT "Identification of six open reading frames in the Salmonella enterica
RT subsp. enterica ser. Typhi viaB locus involved in Vi antigen production.";
RL Res. Microbiol. 144:363-371(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=GIFU 10007;
RX PubMed=8331073; DOI=10.1128/jb.175.14.4456-4465.1993;
RA Hashimoto Y., Li N., Yokoyama H., Ezaki T.;
RT "Complete nucleotide sequence and molecular characterization of ViaB region
RT encoding Vi antigen in Salmonella typhi.";
RL J. Bacteriol. 175:4456-4465(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- PATHWAY: Glycan metabolism; Vi-antigen biosynthesis.
CC -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC family. {ECO:0000305}.
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DR EMBL; X67785; CAA47991.1; -; Genomic_DNA.
DR EMBL; D14156; BAA03192.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD06781.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO71805.1; -; Genomic_DNA.
DR PIR; B36892; B36892.
DR RefSeq; NP_458740.1; NC_003198.1.
DR RefSeq; WP_000466893.1; NZ_WSUR01000012.1.
DR AlphaFoldDB; Q04972; -.
DR SMR; Q04972; -.
DR STRING; 220341.16505431; -.
DR EnsemblBacteria; AAO71805; AAO71805; t4352.
DR KEGG; stt:t4352; -.
DR KEGG; sty:STY4661; -.
DR PATRIC; fig|220341.7.peg.4760; -.
DR eggNOG; COG0677; Bacteria.
DR HOGENOM; CLU_023810_3_1_6; -.
DR OMA; GHCLPID; -.
DR UniPathway; UPA00811; -.
DR UniPathway; UPA00934; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR017476; UDP-Glc/GDP-Man.
DR InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR InterPro; IPR028359; UDP_ManNAc/GlcNAc_DH.
DR Pfam; PF00984; UDPG_MGDP_dh; 1.
DR Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR PIRSF; PIRSF500136; UDP_ManNAc_DH; 1.
DR PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR SUPFAM; SSF48179; SSF48179; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR SUPFAM; SSF52413; SSF52413; 1.
DR TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE 3: Inferred from homology;
KW NAD; Oxidoreductase.
FT CHAIN 1..425
FT /note="Vi polysaccharide biosynthesis protein VipA/TviB"
FT /id="PRO_0000074076"
FT ACT_SITE 261
FT /evidence="ECO:0000250"
FT BINDING 8..25
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000255"
SQ SEQUENCE 425 AA; 47675 MW; B105D5887519B8B5 CRC64;
MFGIDEVKIA IIGLGYVGLP LAVEFGKSRQ VVGFDVNKKR ILELKNGVDV NLETTEEELR
EARYLKFTSE IEKIKECNFY IITVPTPINT YKQPDLTPLI KASETVGTVL NRGDIVVYES
TVYPGCTEEE CVPILARMSG MTFNQDFYVG YSPERINPGD KKHRLTNIKK ITSGSTAQIA
ELIDEVYQQI ISAGTYKAES IKVAEAAKVI ENTQRDLNIA LVNELAIIFN RLNIDTEAVL
RAAGSKWNFL PFRPGLVGGH CIGVDPYYLT HKSQGIGYYP EIILAGRRLN DNMGNYVSEQ
LIKAMIKKGI NVEGSSVLIL GFTFKENCPD IRNTRIIDVV KELGKYSCKV DIFDPWVDAE
EVRREYGIIP VSEVKSSHYD AIIVAVGHQQ FKQMGSEDIR GFGKDKHVLY DLKYVLPAEQ
SDVRL
