ID   VIPB_SALTI              Reviewed;         348 AA.
AC   Q04973;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Vi polysaccharide biosynthesis protein VipB/TviC;
GN   Name=vipB; Synonyms=tviC; OrderedLocusNames=STY4660, t4351;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=8248629; DOI=10.1016/0923-2508(93)90193-6;
RA   Waxin H., Virlogeux I., Kolyva S., Popoff M.Y.;
RT   "Identification of six open reading frames in the Salmonella enterica
RT   subsp. enterica ser. Typhi viaB locus involved in Vi antigen production.";
RL   Res. Microbiol. 144:363-371(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GIFU 10007;
RX   PubMed=8331073; DOI=10.1128/jb.175.14.4456-4465.1993;
RA   Hashimoto Y., Li N., Yokoyama H., Ezaki T.;
RT   "Complete nucleotide sequence and molecular characterization of ViaB region
RT   encoding Vi antigen in Salmonella typhi.";
RL   J. Bacteriol. 175:4456-4465(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- PATHWAY: Glycan metabolism; Vi-antigen biosynthesis.
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; X67785; CAA47992.1; -; Genomic_DNA.
DR   EMBL; D14156; BAA03193.1; -; Genomic_DNA.
DR   EMBL; AL513382; CAD06780.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO71804.1; -; Genomic_DNA.
DR   PIR; C36892; C36892.
DR   RefSeq; NP_458739.1; NC_003198.1.
DR   RefSeq; WP_000127915.1; NZ_WSUR01000012.1.
DR   AlphaFoldDB; Q04973; -.
DR   SMR; Q04973; -.
DR   STRING; 220341.16505430; -.
DR   EnsemblBacteria; AAO71804; AAO71804; t4351.
DR   KEGG; stt:t4351; -.
DR   KEGG; sty:STY4660; -.
DR   PATRIC; fig|220341.7.peg.4759; -.
DR   eggNOG; COG0451; Bacteria.
DR   HOGENOM; CLU_007383_1_7_6; -.
DR   OMA; EPIKVFN; -.
DR   UniPathway; UPA00811; -.
DR   UniPathway; UPA00934; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Lyase; NAD.
FT   CHAIN           1..348
FT                   /note="Vi polysaccharide biosynthesis protein VipB/TviC"
FT                   /id="PRO_0000183256"
FT   ACT_SITE        165
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         17..48
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255"
FT   BINDING         141
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   348 AA;  39503 MW;  79D62BBF15735CE9 CRC64;
     MTAYEELRTK LVLAPKRWLI TGVAGFIGSG LLEELLFLNQ TVIGLDNFST GYQHNLDDVR
     TSVSEEQWSR FIFIQGDIRK FTDCQKACKN VDYVLHQAAL GSVPRSLKDP IATNSANIDG
     FLNMLTAARD AHVSSFTYAA SSSTYGDHPD LPKIEERIGR PLSPYAVTKY VNELYADVFA
     RSYEFNAIGL RYFNVFGRRQ NPNGAYSAVI PRWILSLLKD EPIYINGDGS TSRDFCYIEN
     VIQANLLSAT TNDLASKNKV YNVAVGDRTS LNELYYLIRD GLNLWRNEQS RAEPIYKDFR
     DGDVKHSQAD ITKIKTFLSY EPEFDIKEGL KQTLKWYIDK HSTLYSSV