ID   VIPC_SALTI              Reviewed;         578 AA.
AC   Q04975;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   05-DEC-2001, sequence version 2.
DT   25-MAY-2022, entry version 120.
DE   RecName: Full=Vi polysaccharide biosynthesis protein VipC/TviE;
GN   Name=vipC; Synonyms=tviE; OrderedLocusNames=STY4656, t4349;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=8248629; DOI=10.1016/0923-2508(93)90193-6;
RA   Waxin H., Virlogeux I., Kolyva S., Popoff M.Y.;
RT   "Identification of six open reading frames in the Salmonella enterica
RT   subsp. enterica ser. Typhi viaB locus involved in Vi antigen production.";
RL   Res. Microbiol. 144:363-371(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GIFU 10007;
RX   PubMed=8331073; DOI=10.1128/jb.175.14.4456-4465.1993;
RA   Hashimoto Y., Li N., Yokoyama H., Ezaki T.;
RT   "Complete nucleotide sequence and molecular characterization of ViaB region
RT   encoding Vi antigen in Salmonella typhi.";
RL   J. Bacteriol. 175:4456-4465(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- PATHWAY: Glycan metabolism; Vi-antigen biosynthesis.
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
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DR   EMBL; X67785; CAA47994.1; -; Genomic_DNA.
DR   EMBL; D14156; BAA03195.1; -; Genomic_DNA.
DR   EMBL; AL513382; CAD06776.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO71802.1; -; Genomic_DNA.
DR   PIR; E36892; E36892.
DR   PIR; S28492; S28492.
DR   RefSeq; NP_458735.1; NC_003198.1.
DR   RefSeq; WP_000632616.1; NZ_WSUR01000012.1.
DR   AlphaFoldDB; Q04975; -.
DR   SMR; Q04975; -.
DR   STRING; 220341.16505426; -.
DR   CAZy; GT4; Glycosyltransferase Family 4.
DR   PRIDE; Q04975; -.
DR   EnsemblBacteria; AAO71802; AAO71802; t4349.
DR   KEGG; stt:t4349; -.
DR   KEGG; sty:STY4656; -.
DR   PATRIC; fig|220341.7.peg.4755; -.
DR   eggNOG; COG0438; Bacteria.
DR   HOGENOM; CLU_402077_0_0_6; -.
DR   OMA; IAMKHAI; -.
DR   UniPathway; UPA00811; -.
DR   UniPathway; UPA00934; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
PE   4: Predicted;
FT   CHAIN           1..578
FT                   /note="Vi polysaccharide biosynthesis protein VipC/TviE"
FT                   /id="PRO_0000065835"
FT   CONFLICT        290
FT                   /note="S -> G (in Ref. 1 and 4)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        362..363
FT                   /note="KH -> ND (in Ref. 1; CAA47994)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   578 AA;  65009 MW;  8D420563D868C189 CRC64;
     MITQEEKLAA LGKTCLTLKQ EKKLAQAVAL IDSELPTEAL TSLAMLKKAE FLHDVNETER
     AYALYETLIA QNNDEARYEY ARRLYNTGLA KDAQLILKKV SNGVQKKYNN YLGKINKICD
     LLERLEGKAI PVGTNTCIIA MKHAILFYRN RQPRQLPVGS FGRLALCTGS LGSGGAERQI
     SRLAIEIARK YRQKGKIGGL KVEEPVELII RSLTPELRQD FFLKEVLEEQ VEVLEIAKIT
     GNLFDDATIE SPELRLLLSH LPPVCKYGIK HLVPHLCERK LDYLSVWQDS ACLMIALAAL
     IAGVPRIQLG LRGLPPVVRK RLFKPEYEPL YQALAVVPGV DFMSNNHCVT RHYADWLKLE
     AKHFQVVYNG VLPPSTEPSS EVPHKIWQQF TQKTQDADTT IGGVFRFVGD KNPFAWIDFA
     ARYLQHHPAT RFVLVGDGDL RAEAQKRAEQ LGILERILFV GASRDVGYWL QKMNVFILFS
     RYEGLPNVLI EAQMVGVPVI STPAGGSAEC FIEGVSGFIL DDAQTVNLDQ ACRYAEKLVN
     LWRSRTGICQ QTQSFLQERF TVEHMVGTFV KTIASQPR