ID   VIP_BOVIN               Reviewed;         170 AA.
AC   P81401; Q0VC69; Q8MI77;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 2.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=VIP peptides;
DE   Contains:
DE     RecName: Full=Intestinal peptide PHI-27;
DE     AltName: Full=Peptide histidine isoleucinamide 27;
DE   Contains:
DE     RecName: Full=Vasoactive intestinal peptide;
DE              Short=VIP;
DE     AltName: Full=Vasoactive intestinal polypeptide;
DE   Flags: Precursor;
GN   Name=VIP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12097482; DOI=10.1523/jneurosci.22-13-05310.2002;
RA   Hamelink C., Lee H.-W., Chen Y., Grimaldi M., Eiden L.E.;
RT   "Coincident elevation of cAMP and calcium influx by PACAP-27
RT   synergistically regulates vasoactive intestinal polypeptide gene
RT   transcription through a novel PKA-independent signaling pathway.";
RL   J. Neurosci. 22:5310-5320(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PROTEIN SEQUENCE OF 81-107, AND AMIDATION AT ILE-107.
RC   TISSUE=Duodenum;
RX   PubMed=6548446; DOI=10.1111/j.1432-1033.1984.tb08456.x;
RA   Carlquist M., Kaiser R., Tatemoto K., Joernvall H., Mutt V.;
RT   "A novel form of the polypeptide PHI isolated in high yield from bovine
RT   upper intestine. Relationships to other peptides of the glucagon-secretin
RT   family.";
RL   Eur. J. Biochem. 144:243-247(1984).
RN   [4]
RP   PROTEIN SEQUENCE OF 125-152, AND AMIDATION AT ASN-152.
RC   TISSUE=Intestine;
RX   PubMed=520589; DOI=10.1016/0014-5793(79)80587-6;
RA   Carlquist M., Mutt V., Joernvall H.;
RT   "Isolation and characterization of bovine vasoactive intestinal peptide
RT   (VIP).";
RL   FEBS Lett. 108:457-460(1979).
CC   -!- FUNCTION: VIP causes vasodilation, lowers arterial blood pressure,
CC       stimulates myocardial contractility, increases glycogenolysis and
CC       relaxes the smooth muscle of trachea, stomach and gall bladder.
CC   -!- FUNCTION: PHI also causes vasodilation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MISCELLANEOUS: X's at positions 28 to 44 were included by homology with
CC       the human precursor sequence.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   EMBL; AF503910; AAM28152.1; -; mRNA.
DR   EMBL; BC120324; AAI20325.1; -; mRNA.
DR   RefSeq; NP_776395.1; NM_173970.3.
DR   AlphaFoldDB; P81401; -.
DR   SMR; P81401; -.
DR   STRING; 9913.ENSBTAP00000017827; -.
DR   PaxDb; P81401; -.
DR   Ensembl; ENSBTAT00000017827; ENSBTAP00000017827; ENSBTAG00000013400.
DR   GeneID; 280956; -.
DR   KEGG; bta:280956; -.
DR   CTD; 7432; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013400; -.
DR   VGNC; VGNC:36797; VIP.
DR   eggNOG; ENOG502QVTA; Eukaryota.
DR   GeneTree; ENSGT00950000183154; -.
DR   HOGENOM; CLU_133877_1_0_1; -.
DR   InParanoid; P81401; -.
DR   OMA; MDRNTRH; -.
DR   OrthoDB; 1343108at2759; -.
DR   TreeFam; TF332804; -.
DR   Reactome; R-BTA-420092; Glucagon-type ligand receptors.
DR   Proteomes; UP000009136; Chromosome 9.
DR   Bgee; ENSBTAG00000013400; Expressed in caecum and 40 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0043204; C:perikaryon; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IDA:BHF-UCL.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR   GO; GO:0051428; F:peptide hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:BHF-UCL.
DR   GO; GO:0048242; P:epinephrine secretion; IBA:GO_Central.
DR   GO; GO:0007611; P:learning or memory; IBA:GO_Central.
DR   GO; GO:0048255; P:mRNA stabilization; ISS:AgBase.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR   GO; GO:0043267; P:negative regulation of potassium ion transport; IBA:GO_Central.
DR   GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IBA:GO_Central.
DR   GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IBA:GO_Central.
DR   GO; GO:0032812; P:positive regulation of epinephrine secretion; IBA:GO_Central.
DR   GO; GO:0060406; P:positive regulation of penile erection; IBA:GO_Central.
DR   GO; GO:0045732; P:positive regulation of protein catabolic process; IDA:BHF-UCL.
DR   GO; GO:0070459; P:prolactin secretion; ISS:AgBase.
DR   GO; GO:0032880; P:regulation of protein localization; IDA:BHF-UCL.
DR   GO; GO:0051930; P:regulation of sensory perception of pain; IBA:GO_Central.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   InterPro; IPR015523; VIP.
DR   PANTHER; PTHR11213; PTHR11213; 1.
DR   PANTHER; PTHR11213:SF5; PTHR11213:SF5; 1.
DR   Pfam; PF00123; Hormone_2; 2.
DR   SMART; SM00070; GLUCA; 2.
DR   PROSITE; PS00260; GLUCAGON; 2.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..79
FT                   /id="PRO_0000011450"
FT   PEPTIDE         81..107
FT                   /note="Intestinal peptide PHI-27"
FT                   /id="PRO_0000011451"
FT   PROPEP          111..122
FT                   /id="PRO_0000011452"
FT   PEPTIDE         125..152
FT                   /note="Vasoactive intestinal peptide"
FT                   /id="PRO_0000011453"
FT   PROPEP          156..170
FT                   /id="PRO_0000011454"
FT   MOD_RES         76
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01283"
FT   MOD_RES         107
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000269|PubMed:6548446"
FT   MOD_RES         152
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000269|PubMed:520589"
SQ   SEQUENCE   170 AA;  19165 MW;  9C6A6049AF7BFF81 CRC64;
     METRSKPQLL VFLTLFSVLF SQTLAWPLFG APSALRMGDR IPFEGANEPD QVSLKADTDI
     LQDALAENDT PYYDVSRNVR HADGVFTSDY SRLLGQLSAK KYLESLIGKR VSNSISEDQG
     PIKRHSDAVF TDNYTRLRKQ MAVKKYLNSI LNGKRSSEGE SPDFLEELEK