VIP_CHICK
ID VIP_CHICK Reviewed; 200 AA.
AC P48143; P01285;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=VIP peptides;
DE Contains:
DE RecName: Full=Intestinal peptide PHI-27-like;
DE Contains:
DE RecName: Full=Vasoactive intestinal peptide;
DE Short=VIP;
DE AltName: Full=Vasoactive intestinal polypeptide;
DE Flags: Precursor;
GN Name=VIP;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=7890166; DOI=10.1016/0378-1119(94)00856-n;
RA McFarlin D.R., Lehn D.A., Moran S.M., MacDonald M.J., Epstein M.L.;
RT "Sequence of a cDNA encoding chicken vasoactive intestinal peptide (VIP).";
RL Gene 154:211-213(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-84 AND 120-200.
RC TISSUE=Hypothalamus;
RA Talbot R.T., Dunn I.C., Wilson P.W., Sang H.M., Sharp P.J.;
RL Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PROTEIN SEQUENCE OF 129-156, AND AMIDATION AT THR-156.
RX PubMed=1227973; DOI=10.1016/0014-5793(75)80740-x;
RA Nilsson A.;
RT "Structure of the vasoactive intestinal octacosapeptide from chicken
RT intestine. The amino acid sequence.";
RL FEBS Lett. 60:322-326(1975).
RN [4]
RP SYNTHESIS OF VIP, AND PROTEIN SEQUENCE OF 139-156.
RA Bodanszky M., Lin C.Y., Yiotakis A.E., Mutt V., Said S.I.;
RT "Vasoactive intestinal peptide (VIP) from chicken. Synthesis and properties
RT of the C-terminal hendecapeptide.";
RL Bioorg. Chem. 5:339-350(1976).
CC -!- FUNCTION: VIP causes vasodilation, lowers arterial blood pressure,
CC stimulates myocardial contractility, increases glycogenolysis and
CC relaxes the smooth muscle of trachea, stomach and gall bladder.
CC -!- FUNCTION: PHI also causes vasodilation.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=P48143-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=P48143-2; Sequence=VSP_001758;
CC -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR EMBL; U09350; AAA87896.1; -; mRNA.
DR EMBL; X80906; CAA56867.1; -; mRNA.
DR PIR; S47470; VRCH.
DR RefSeq; NP_001170780.1; NM_001177309.1. [P48143-2]
DR AlphaFoldDB; P48143; -.
DR SMR; P48143; -.
DR STRING; 9031.ENSGALP00000040805; -.
DR PaxDb; P48143; -.
DR Ensembl; ENSGALT00000022132; ENSGALP00000022093; ENSGALG00000013604. [P48143-2]
DR Ensembl; ENSGALT00000108045; ENSGALP00000069501; ENSGALG00000013604. [P48143-2]
DR GeneID; 396323; -.
DR KEGG; gga:396323; -.
DR CTD; 7432; -.
DR VEuPathDB; HostDB:geneid_396323; -.
DR eggNOG; ENOG502QVTA; Eukaryota.
DR GeneTree; ENSGT00950000183154; -.
DR InParanoid; P48143; -.
DR OrthoDB; 1343108at2759; -.
DR PhylomeDB; P48143; -.
DR Reactome; R-GGA-418555; G alpha (s) signalling events.
DR Reactome; R-GGA-420092; Glucagon-type ligand receptors.
DR PRO; PR:P48143; -.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000013604; Expressed in colon and 8 other tissues.
DR ExpressionAtlas; P48143; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; TAS:AgBase.
DR GO; GO:0043005; C:neuron projection; IDA:AgBase.
DR GO; GO:0043204; C:perikaryon; IBA:GO_Central.
DR GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR GO; GO:0051428; F:peptide hormone receptor binding; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:AgBase.
DR GO; GO:0048242; P:epinephrine secretion; IMP:AgBase.
DR GO; GO:0010467; P:gene expression; IMP:AgBase.
DR GO; GO:0007611; P:learning or memory; IBA:GO_Central.
DR GO; GO:0048255; P:mRNA stabilization; ISS:AgBase.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0043267; P:negative regulation of potassium ion transport; IBA:GO_Central.
DR GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IBA:GO_Central.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IBA:GO_Central.
DR GO; GO:0032812; P:positive regulation of epinephrine secretion; IMP:AgBase.
DR GO; GO:0010628; P:positive regulation of gene expression; TAS:AgBase.
DR GO; GO:0060406; P:positive regulation of penile erection; IBA:GO_Central.
DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IMP:AgBase.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IBA:GO_Central.
DR GO; GO:0070459; P:prolactin secretion; IMP:AgBase.
DR GO; GO:0032880; P:regulation of protein localization; IBA:GO_Central.
DR GO; GO:0051930; P:regulation of sensory perception of pain; IBA:GO_Central.
DR InterPro; IPR015550; Glucagon.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR InterPro; IPR015523; VIP.
DR PANTHER; PTHR11213; PTHR11213; 1.
DR PANTHER; PTHR11213:SF5; PTHR11213:SF5; 1.
DR Pfam; PF00123; Hormone_2; 2.
DR SMART; SM00070; GLUCA; 2.
DR PROSITE; PS00260; GLUCAGON; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW Direct protein sequencing; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT PROPEP 26..87
FT /id="PRO_0000011476"
FT PEPTIDE 89..115
FT /note="Intestinal peptide PHI-27-like"
FT /id="PRO_0000011477"
FT PROPEP 119..126
FT /id="PRO_0000011478"
FT PEPTIDE 129..156
FT /note="Vasoactive intestinal peptide"
FT /id="PRO_0000011479"
FT PROPEP 160..200
FT /id="PRO_0000011480"
FT MOD_RES 156
FT /note="Threonine amide"
FT /evidence="ECO:0000269|PubMed:1227973"
FT VAR_SEQ 85..119
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000305"
FT /id="VSP_001758"
SQ SEQUENCE 200 AA; 22540 MW; 902A88F998CAB402 CRC64;
MEHRGASPLL LALALLSALC WRARALPPRG AAFPAVPRLG NRLPFDAASE SDRAHGSLKS
ESDILQNTLP ENEKFYFDLS RIIDRNARHA DGIFTSVYSH LLAKLAVKRY LHSLIRKRVS
SQDSPVKRHS DAVFTDNYSR FRKQMAVKKY LNSVLTGKRS QEELNPAKLR GEAEILEPSF
SENYDDVSVD ELLSHLPLDL
