ID   VIP_DIDVI               Reviewed;          28 AA.
AC   P39089;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Vasoactive intestinal peptide;
DE            Short=VIP;
DE   AltName: Full=Vasoactive intestinal polypeptide;
GN   Name=VIP;
OS   Didelphis virginiana (North American opossum) (Didelphis marsupialis
OS   virginiana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Didelphimorphia; Didelphidae; Didelphis.
OX   NCBI_TaxID=9267;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=1542675; DOI=10.1073/pnas.89.5.1809;
RA   Eng J., Yu J.-H., Rattan S., Yalow R.S.;
RT   "Isolation and amino acid sequences of opossum vasoactive intestinal
RT   polypeptide and cholecystokinin octapeptide.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:1809-1811(1992).
CC   -!- FUNCTION: VIP causes vasodilation, lowers arterial blood pressure,
CC       stimulates myocardial contractility, increases glycogenolysis and
CC       relaxes the smooth muscle of trachea, stomach and gall bladder.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   PIR; A38232; A38232.
DR   AlphaFoldDB; P39089; -.
DR   SMR; P39089; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   Pfam; PF00123; Hormone_2; 1.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..28
FT                   /note="Vasoactive intestinal peptide"
FT                   /id="PRO_0000043941"
FT   MOD_RES         28
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P01282"
SQ   SEQUENCE   28 AA;  3318 MW;  F01188A0A72F76D9 CRC64;
     HSDAVFTDSY TRLLKQMAMR KYLDSILN