ID   VIP_MACMU               Reviewed;          28 AA.
AC   P84488;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Vasoactive intestinal peptide;
DE            Short=VIP;
DE   AltName: Full=Vasoactive intestinal polypeptide;
GN   Name=VIP;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2003150; DOI=10.1016/0167-0115(91)90005-2;
RA   Yu J.-H., Xin Y., Eng J., Yalow R.S.;
RT   "Rhesus monkey gastroenteropancreatic hormones: relationship to human
RT   sequences.";
RL   Regul. Pept. 32:39-45(1991).
CC   -!- FUNCTION: VIP causes vasodilation, lowers arterial blood pressure,
CC       stimulates myocardial contractility, increases glycogenolysis and
CC       relaxes the smooth muscle of trachea, stomach and gall bladder.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; B60071; B60071.
DR   AlphaFoldDB; P84488; -.
DR   SMR; P84488; -.
DR   eggNOG; ENOG502QVTA; Eukaryota.
DR   HOGENOM; CLU_133877_1_0_1; -.
DR   InParanoid; P84488; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:UniProt.
DR   GO; GO:0048255; P:mRNA stabilization; ISS:AgBase.
DR   GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:UniProt.
DR   GO; GO:0070459; P:prolactin secretion; ISS:AgBase.
DR   GO; GO:0032880; P:regulation of protein localization; IEA:UniProt.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   InterPro; IPR015523; VIP.
DR   PANTHER; PTHR11213; PTHR11213; 1.
DR   PANTHER; PTHR11213:SF5; PTHR11213:SF5; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Reference proteome;
KW   Secreted.
FT   PEPTIDE         1..28
FT                   /note="Vasoactive intestinal peptide"
FT                   /id="PRO_0000043942"
FT   MOD_RES         28
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P01282"
SQ   SEQUENCE   28 AA;  3327 MW;  EF313FB573FF6F3F CRC64;
     HSDAVFTDNY TRLRKQMAVK KYLNSILN