ID   VIP_MELGA               Reviewed;         200 AA.
AC   P45644;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=VIP peptides;
DE   Contains:
DE     RecName: Full=Intestinal peptide PHI-27-like;
DE   Contains:
DE     RecName: Full=Vasoactive intestinal peptide;
DE              Short=VIP;
DE     AltName: Full=Vasoactive intestinal polypeptide;
DE   Flags: Precursor;
GN   Name=VIP;
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Nicholas white; TISSUE=Hypothalamus;
RX   PubMed=7750483; DOI=10.1210/endo.136.6.7750483;
RA   You S., Silsby J.L., Farris J.A., Foster D.N., el Halawani M.E.;
RT   "Tissue-specific alternative splicing of turkey preprovasoactive intestinal
RT   peptide messenger ribonucleic acid, its regulation, and correlation with
RT   prolactin secretion.";
RL   Endocrinology 136:2602-2610(1995).
CC   -!- FUNCTION: VIP causes vasodilation, lowers arterial blood pressure,
CC       stimulates myocardial contractility, increases glycogenolysis and
CC       relaxes the smooth muscle of trachea, stomach and gall bladder.
CC   -!- FUNCTION: PHI also causes vasodilation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   EMBL; L36641; AAA92866.1; -; mRNA.
DR   AlphaFoldDB; P45644; -.
DR   SMR; P45644; -.
DR   PRIDE; P45644; -.
DR   InParanoid; P45644; -.
DR   Proteomes; UP000001645; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; TAS:AgBase.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0005184; F:neuropeptide hormone activity; TAS:AgBase.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISS:AgBase.
DR   GO; GO:0048255; P:mRNA stabilization; IDA:AgBase.
DR   GO; GO:0009648; P:photoperiodism; TAS:AgBase.
DR   GO; GO:0010524; P:positive regulation of calcium ion transport into cytosol; IDA:AgBase.
DR   GO; GO:0010628; P:positive regulation of gene expression; IDA:AgBase.
DR   GO; GO:0010604; P:positive regulation of macromolecule metabolic process; IEA:UniProt.
DR   GO; GO:0090277; P:positive regulation of peptide hormone secretion; TAS:AgBase.
DR   GO; GO:0060050; P:positive regulation of protein glycosylation; IDA:AgBase.
DR   GO; GO:0070459; P:prolactin secretion; IDA:AgBase.
DR   GO; GO:0032879; P:regulation of localization; IEA:UniProt.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   InterPro; IPR015523; VIP.
DR   PANTHER; PTHR11213; PTHR11213; 1.
DR   PANTHER; PTHR11213:SF5; PTHR11213:SF5; 1.
DR   Pfam; PF00123; Hormone_2; 2.
DR   SMART; SM00070; GLUCA; 2.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..87
FT                   /id="PRO_0000011481"
FT   PEPTIDE         89..115
FT                   /note="Intestinal peptide PHI-27-like"
FT                   /id="PRO_0000011482"
FT   PROPEP          119..126
FT                   /id="PRO_0000011483"
FT   PEPTIDE         129..156
FT                   /note="Vasoactive intestinal peptide"
FT                   /id="PRO_0000011484"
FT   PROPEP          160..200
FT                   /id="PRO_0000011485"
FT   MOD_RES         156
FT                   /note="Threonine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   200 AA;  22601 MW;  B35933495273F06D CRC64;
     MEHRGTSPLL LALALLSALC WRARALPPRG AAFPAVPRLG NRLPFDAASE SDRAHGSLKS
     ESDILQNTLP ENEKFYFDLS RIIDRNDRHA DGIFTTVYSH LLAKLAVKRY LHSLIRKRVS
     SQDSPVKRHS DAVFTDNYSR FRKQMAVKKY LNSVLTGKRS QEELNPAKLA DEAEILEPSF
     SENYDDVSVD ELLSHLPLDL