ID   VIP_PELRI               Reviewed;          28 AA.
AC   P81016;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Vasoactive intestinal peptide;
DE            Short=VIP;
DE   AltName: Full=Vasoactive intestinal polypeptide;
GN   Name=vip;
OS   Pelophylax ridibundus (Marsh frog) (Rana ridibunda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Pelophylax.
OX   NCBI_TaxID=8406;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=7540547; DOI=10.1210/endo.136.7.7540547;
RA   Chartrel N., Wang Y., Fournier A., Vaudry H., Conlon J.M.;
RT   "Frog vasoactive intestinal polypeptide and galanin: primary structures and
RT   effects on pituitary adenylate cyclase.";
RL   Endocrinology 136:3079-3086(1995).
CC   -!- FUNCTION: VIP causes vasodilation, lowers arterial blood pressure,
CC       stimulates myocardial contractility, increases glycogenolysis and
CC       relaxes the smooth muscle of trachea, stomach and gall bladder.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   AlphaFoldDB; P81016; -.
DR   SMR; P81016; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0048255; P:mRNA stabilization; ISS:AgBase.
DR   GO; GO:0070459; P:prolactin secretion; ISS:AgBase.
DR   GO; GO:0032879; P:regulation of localization; IEA:UniProt.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   InterPro; IPR015523; VIP.
DR   PANTHER; PTHR11213; PTHR11213; 1.
DR   PANTHER; PTHR11213:SF5; PTHR11213:SF5; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..28
FT                   /note="Vasoactive intestinal peptide"
FT                   /id="PRO_0000043945"
FT   MOD_RES         28
FT                   /note="Threonine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P48143"
SQ   SEQUENCE   28 AA;  3320 MW;  17B42D7573FF6F37 CRC64;
     HSDAVFTDNY SRFRKQMAVK KYLNSVLT