VIP_PIG
ID VIP_PIG Reviewed; 75 AA.
AC P01284; Q9TRN0;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 23-FEB-2022, entry version 92.
DE RecName: Full=VIP peptides;
DE Contains:
DE RecName: Full=Intestinal peptide PHI-27;
DE AltName: Full=Peptide histidine isoleucinamide 27;
DE Contains:
DE RecName: Full=Vasoactive intestinal peptide;
DE Short=VIP;
DE AltName: Full=Vasoactive intestinal polypeptide;
DE Flags: Precursor; Fragment;
GN Name=VIP;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP PROTEIN SEQUENCE OF 1-27, AND AMIDATION AT ILE-27.
RX PubMed=6947244; DOI=10.1073/pnas.78.11.6603;
RA Tatemoto K., Mutt V.;
RT "Isolation and characterization of the intestinal peptide porcine PHI (PHI-
RT 27), a new member of the glucagon-secretin family.";
RL Proc. Natl. Acad. Sci. U.S.A. 78:6603-6607(1981).
RN [2]
RP PROTEIN SEQUENCE OF 1-24.
RC TISSUE=Duodenum;
RX PubMed=1329741; DOI=10.1016/0006-291x(92)90484-3;
RA Ichiki Y., Kitamura K., Kangawa K., Kawamoto M., Matsuo H., Eto T.;
RT "Organ distribution and characterization of porcine peptides (VIP, CGRP and
RT PHI) that increase cAMP in rat platelets.";
RL Biochem. Biophys. Res. Commun. 187:1587-1593(1992).
RN [3]
RP PROTEIN SEQUENCE OF 45-75.
RX PubMed=2843830; DOI=10.1016/0196-9781(88)90149-0;
RA Gafvelin G., Andersson M., Dimaline R., Joernvall H., Mutt V.;
RT "Isolation and characterization of a variant form of vasoactive intestinal
RT polypeptide.";
RL Peptides 9:469-474(1988).
RN [4]
RP PROTEIN SEQUENCE OF 45-72, AND AMIDATION AT ASN-72.
RX PubMed=4829446; DOI=10.1111/j.1432-1033.1974.tb03373.x;
RA Mutt V., Said S.I.;
RT "Structure of the porcine vasoactive intestinal octacosapeptide. The amino-
RT acid sequence. Use of kallikrein in its determination.";
RL Eur. J. Biochem. 42:581-589(1974).
RN [5]
RP SYNTHESIS OF VIP.
RX PubMed=4854585; DOI=10.1021/ja00822a041;
RA Bodanszky M., Klausner Y.S., Lin C.Y., Mutt V., Said S.I.;
RT "Synthesis of the vasoactive intestinal peptide (VIP).";
RL J. Am. Chem. Soc. 96:4973-4978(1974).
CC -!- FUNCTION: VIP causes vasodilation, lowers arterial blood pressure,
CC stimulates myocardial contractility, increases glycogenolysis and
CC relaxes the smooth muscle of trachea, stomach and gall bladder.
CC -!- FUNCTION: PHM-27 is a potent agonist of the calcitonin receptor CALCR,
CC with similar efficacy as calcitonin (By similarity). PHI also causes
CC vasodilation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- MISCELLANEOUS: X's at positions 28 to 44 were included by homology with
CC the human precursor sequence.
CC -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR PIR; A01549; VRPG.
DR BMRB; P01284; -.
DR STRING; 9823.ENSSSCP00000004405; -.
DR InParanoid; P01284; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0043204; C:perikaryon; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IDA:BHF-UCL.
DR GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR GO; GO:0051428; F:peptide hormone receptor binding; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:BHF-UCL.
DR GO; GO:0048242; P:epinephrine secretion; IBA:GO_Central.
DR GO; GO:0007611; P:learning or memory; IBA:GO_Central.
DR GO; GO:0048255; P:mRNA stabilization; ISS:AgBase.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0043267; P:negative regulation of potassium ion transport; IBA:GO_Central.
DR GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IBA:GO_Central.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IBA:GO_Central.
DR GO; GO:0032812; P:positive regulation of epinephrine secretion; IBA:GO_Central.
DR GO; GO:0060406; P:positive regulation of penile erection; IBA:GO_Central.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IDA:BHF-UCL.
DR GO; GO:0070459; P:prolactin secretion; ISS:AgBase.
DR GO; GO:0032880; P:regulation of protein localization; IDA:BHF-UCL.
DR GO; GO:0051930; P:regulation of sensory perception of pain; IBA:GO_Central.
DR InterPro; IPR015550; Glucagon.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR InterPro; IPR015523; VIP.
DR PANTHER; PTHR11213; PTHR11213; 1.
DR PANTHER; PTHR11213:SF5; PTHR11213:SF5; 1.
DR Pfam; PF00123; Hormone_2; 2.
DR SMART; SM00070; GLUCA; 2.
DR PROSITE; PS00260; GLUCAGON; 2.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Hormone; Reference proteome; Secreted.
FT PEPTIDE 1..27
FT /note="Intestinal peptide PHI-27"
FT /id="PRO_0000011467"
FT PEPTIDE 45..72
FT /note="Vasoactive intestinal peptide"
FT /id="PRO_0000011468"
FT MOD_RES 27
FT /note="Isoleucine amide"
FT /evidence="ECO:0000269|PubMed:6947244"
FT MOD_RES 72
FT /note="Asparagine amide"
FT /evidence="ECO:0000269|PubMed:4829446"
FT NON_TER 1
FT NON_TER 75
SQ SEQUENCE 75 AA; 8539 MW; C109FB1F03B1F0E5 CRC64;
HADGVFTSDF SRLLGQLSAK KYLESLIXXX XXXXXXXXXX XXXXHSDAVF TDNYTRLRKQ
MAVKKYLNSI LNGKR
