ID   VIP_SCYCA               Reviewed;          28 AA.
AC   P09685;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Vasoactive intestinal peptide;
DE            Short=VIP;
DE   AltName: Full=Vasoactive intestinal polypeptide;
GN   Name=vip;
OS   Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC   Scyliorhinus.
OX   NCBI_TaxID=7830;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT ALA-28.
RX   PubMed=2441759; DOI=10.1016/0167-4889(87)90160-1;
RA   Dimaline R., Young J., Thwaites D.T., Lee C.M., Shuttleworth T.J.,
RA   Thorndyke M.C.;
RT   "A novel vasoactive intestinal peptide (VIP) from elasmobranch intestine
RT   has full affinity for mammalian pancreatic VIP receptors.";
RL   Biochim. Biophys. Acta 930:97-100(1987).
RN   [2]
RP   PROTEIN SEQUENCE.
RA   Dimaline R., Young J., Thwaites D.T., Lee C.M., Thorndyke M.C.;
RT   "Amino acid sequence of a biologically active vasoactive intestinal peptide
RT   from the elasmobranch Scyliorhinus canicula.";
RL   Ann. N. Y. Acad. Sci. 527:621-623(1988).
RN   [3]
RP   PROTEIN SEQUENCE OF 1-10.
RX   PubMed=3715063; DOI=10.1016/0167-0115(86)90200-4;
RA   Dimaline R., Thorndyke M.C., Young J.;
RT   "Isolation and partial sequence of elasmobranch VIP.";
RL   Regul. Pept. 14:1-10(1986).
CC   -!- FUNCTION: VIP causes vasodilation, lowers arterial blood pressure,
CC       stimulates myocardial contractility, increases glycogenolysis and
CC       relaxes the smooth muscle of trachea, stomach and gall bladder.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   PIR; A60303; A60303.
DR   AlphaFoldDB; P09685; -.
DR   SMR; P09685; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0048255; P:mRNA stabilization; ISS:AgBase.
DR   GO; GO:0070459; P:prolactin secretion; ISS:AgBase.
DR   GO; GO:0032879; P:regulation of localization; IEA:UniProt.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   InterPro; IPR015523; VIP.
DR   PANTHER; PTHR11213; PTHR11213; 1.
DR   PANTHER; PTHR11213:SF5; PTHR11213:SF5; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..28
FT                   /note="Vasoactive intestinal peptide"
FT                   /id="PRO_0000043946"
FT   MOD_RES         28
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000269|PubMed:2441759"
SQ   SEQUENCE   28 AA;  3270 MW;  9014389573F81F3B CRC64;
     HSDAVFTDNY SRIRKQMAVK KYINSLLA