ID   VIP_SHEEP               Reviewed;          28 AA.
AC   P63291; P04565;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Vasoactive intestinal peptide;
DE            Short=VIP;
DE   AltName: Full=Vasoactive intestinal polypeptide;
GN   Name=VIP;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Brain;
RX   PubMed=2235680; DOI=10.1016/0196-9781(90)90184-7;
RA   Gafvelin G.;
RT   "Isolation and primary structure of VIP from sheep brain.";
RL   Peptides 11:703-706(1990).
RN   [2]
RP   PROTEIN SEQUENCE, AND AMIDATION AT ASN-28.
RC   TISSUE=Small intestine;
RX   PubMed=2034821; DOI=10.1016/0167-0115(91)90044-h;
RA   Bounjoua Y., Vandermeers A., Robberecht P., Vandermeers-Piret M.C.,
RA   Christophe J.;
RT   "Purification and amino acid sequence of vasoactive intestinal peptide,
RT   peptide histidine isoleucinamide and secretin from the ovine small
RT   intestine.";
RL   Regul. Pept. 32:169-179(1991).
RN   [3]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Hypothalamus, and Intestine;
RX   PubMed=1574609; DOI=10.1016/0167-0115(92)90053-w;
RA   Miyata A., Jiang L., Stibbs H.H., Arimura A.;
RT   "Chemical characterization of vasoactive intestinal polypeptide-like
RT   immunoreactivity in ovine hypothalamus and intestine.";
RL   Regul. Pept. 38:145-154(1992).
CC   -!- FUNCTION: VIP causes vasodilation, lowers arterial blood pressure,
CC       stimulates myocardial contractility, increases glycogenolysis and
CC       relaxes the smooth muscle of trachea, stomach and gall bladder.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   PIR; B60072; VRSH.
DR   AlphaFoldDB; P63291; -.
DR   SMR; P63291; -.
DR   eggNOG; ENOG502QVTA; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:UniProt.
DR   GO; GO:0048255; P:mRNA stabilization; ISS:AgBase.
DR   GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:UniProt.
DR   GO; GO:0070459; P:prolactin secretion; ISS:AgBase.
DR   GO; GO:0032880; P:regulation of protein localization; IEA:UniProt.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   InterPro; IPR015523; VIP.
DR   PANTHER; PTHR11213; PTHR11213; 1.
DR   PANTHER; PTHR11213:SF5; PTHR11213:SF5; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Reference proteome;
KW   Secreted.
FT   PEPTIDE         1..28
FT                   /note="Vasoactive intestinal peptide"
FT                   /id="PRO_0000043943"
FT   MOD_RES         28
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000269|PubMed:2034821"
SQ   SEQUENCE   28 AA;  3327 MW;  EF313FB573FF6F3F CRC64;
     HSDAVFTDNY TRLRKQMAVK KYLNSILN