ID   VIR17_SALTY             Reviewed;         144 AA.
AC   Q8ZM36;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Virulence protein STM3117;
GN   OrderedLocusNames=STM3117;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   INDUCTION.
RX   PubMed=12492857; DOI=10.1046/j.1365-2958.2003.03313.x;
RA   Eriksson S., Lucchini S., Thompson A., Rhen M., Hinton J.C.;
RT   "Unravelling the biology of macrophage infection by gene expression
RT   profiling of intracellular Salmonella enterica.";
RL   Mol. Microbiol. 47:103-118(2003).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, AND INDUCTION.
RC   STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX   PubMed=16893888; DOI=10.1074/jbc.m604640200;
RA   Shi L., Adkins J.N., Coleman J.R., Schepmoes A.A., Dohnkova A.,
RA   Mottaz H.M., Norbeck A.D., Purvine S.O., Manes N.P., Smallwood H.S.,
RA   Wang H., Forbes J., Gros P., Uzzau S., Rodland K.D., Heffron F.,
RA   Smith R.D., Squier T.C.;
RT   "Proteomic analysis of Salmonella enterica serovar typhimurium isolated
RT   from RAW 264.7 macrophages: identification of a novel protein that
RT   contributes to the replication of serovar typhimurium inside macrophages.";
RL   J. Biol. Chem. 281:29131-29140(2006).
CC   -!- FUNCTION: Is critically involved in promoting the replication of
CC       S.typhimurium cells inside host macrophages, suggesting a role in the
CC       establishment of bacterial colonization within macrophages. May be
CC       involved in the biosynthesis and modification of the peptidoglycan
CC       layer of the cell wall. {ECO:0000269|PubMed:16893888}.
CC   -!- INDUCTION: Up-regulated following infection of host macrophages.
CC       {ECO:0000269|PubMed:12492857, ECO:0000269|PubMed:16893888}.
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DR   EMBL; AE006468; AAL21991.1; -; Genomic_DNA.
DR   RefSeq; NP_462032.1; NC_003197.2.
DR   RefSeq; WP_001673714.1; NC_003197.2.
DR   PDB; 3HNQ; X-ray; 2.10 A; A/B/C/D=1-144.
DR   PDB; 3HUH; X-ray; 1.50 A; A/B/C/D=4-144.
DR   PDBsum; 3HNQ; -.
DR   PDBsum; 3HUH; -.
DR   AlphaFoldDB; Q8ZM36; -.
DR   SMR; Q8ZM36; -.
DR   STRING; 99287.STM3117; -.
DR   PaxDb; Q8ZM36; -.
DR   DNASU; 1254640; -.
DR   EnsemblBacteria; AAL21991; AAL21991; STM3117.
DR   GeneID; 1254640; -.
DR   KEGG; stm:STM3117; -.
DR   HOGENOM; CLU_046006_4_3_6; -.
DR   OMA; PPPCFIQ; -.
DR   PhylomeDB; Q8ZM36; -.
DR   BioCyc; SENT99287:STM3117-MON; -.
DR   BRENDA; 4.4.1.5; 5542.
DR   EvolutionaryTrace; Q8ZM36; -.
DR   Proteomes; UP000001014; Chromosome.
DR   Gene3D; 3.10.180.10; -; 1.
DR   InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR   InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR   InterPro; IPR037523; VOC.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   SUPFAM; SSF54593; SSF54593; 1.
DR   PROSITE; PS51819; VOC; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Virulence.
FT   CHAIN           1..144
FT                   /note="Virulence protein STM3117"
FT                   /id="PRO_0000272960"
FT   DOMAIN          23..143
FT                   /note="VOC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT   STRAND          21..32
FT                   /evidence="ECO:0007829|PDB:3HUH"
FT   HELIX           34..43
FT                   /evidence="ECO:0007829|PDB:3HUH"
FT   STRAND          48..52
FT                   /evidence="ECO:0007829|PDB:3HUH"
FT   TURN            53..55
FT                   /evidence="ECO:0007829|PDB:3HUH"
FT   STRAND          56..61
FT                   /evidence="ECO:0007829|PDB:3HUH"
FT   STRAND          64..70
FT                   /evidence="ECO:0007829|PDB:3HUH"
FT   STRAND          75..77
FT                   /evidence="ECO:0007829|PDB:3HNQ"
FT   STRAND          88..95
FT                   /evidence="ECO:0007829|PDB:3HUH"
FT   HELIX           97..106
FT                   /evidence="ECO:0007829|PDB:3HUH"
FT   STRAND          112..120
FT                   /evidence="ECO:0007829|PDB:3HUH"
FT   STRAND          123..131
FT                   /evidence="ECO:0007829|PDB:3HUH"
FT   STRAND          137..142
FT                   /evidence="ECO:0007829|PDB:3HUH"
SQ   SEQUENCE   144 AA;  16147 MW;  4234A2F02BE9F4E4 CRC64;
     MLFFNVASLK YKHHESIQMI IDRIDHLVLT VSDISTTIRF YEEVLGFSAV TFKQNRKALI
     FGAQKINLHQ QEMEFEPKAS RPTPGSADLC FITSTPINDV VSEILQAGIS IVEGPVERTG
     ATGEIMSIYI RDPDGNLIEI SQYV