ID   VIRB1_BRUSU             Reviewed;         238 AA.
AC   Q9RPY4; G0KER7; Q7CEF9;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Type IV secretion system protein virB1;
GN   Name=virB1; OrderedLocusNames=BRA0069, BS1330_II0069;
OS   Brucella suis biovar 1 (strain 1330).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=204722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=1330;
RX   PubMed=10510235; DOI=10.1046/j.1365-2958.1999.01569.x;
RA   O'Callaghan D., Cazevieille C., Allardet-Servent A., Boschiroli M.L.,
RA   Bourg G., Foulongne V., Frutos P., Kulakov Y., Ramuz M.;
RT   "A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis
RT   Ptl type IV secretion systems is essential for intracellular survival of
RT   Brucella suis.";
RL   Mol. Microbiol. 33:1210-1220(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND EXPRESSION CONDITIONS.
RC   STRAIN=1330;
RX   PubMed=11830669; DOI=10.1073/pnas.032514299;
RA   Boschiroli M.L., Ouahrani-Bettache S., Foulongne V., Michaux-Charachon S.,
RA   Bourg G., Allardet-Servent A., Cazevieille C., Liautard J.P., Ramuz M.,
RA   O'Callaghan D.;
RT   "The Brucella suis virB operon is induced intracellularly in macrophages.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:1544-1549(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=12271122; DOI=10.1073/pnas.192319099;
RA   Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA   Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA   Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA   Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT   "The Brucella suis genome reveals fundamental similarities between animal
RT   and plant pathogens and symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=22038969; DOI=10.1128/jb.06181-11;
RA   Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT   "Revised genome sequence of Brucella suis 1330.";
RL   J. Bacteriol. 193:6410-6410(2011).
CC   -!- FUNCTION: The VirB system could be required for the establishment of
CC       the replication niche in the host. {ECO:0000269|PubMed:10510235}.
CC   -!- INDUCTION: Specifically induced within macrophages by phagosome
CC       acidification. Induced at 37 degrees Celsius in minimal medium,
CC       suggesting that nutritional stress is a regulating signal.
CC   -!- MISCELLANEOUS: Transcription of the operon is maximal in early
CC       exponential phase.
CC   -!- SIMILARITY: Belongs to the virb1 family. {ECO:0000305}.
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DR   EMBL; AF141604; AAD56611.1; -; Genomic_DNA.
DR   EMBL; AE014292; AAN33281.1; -; Genomic_DNA.
DR   EMBL; CP002998; AEM19561.1; -; Genomic_DNA.
DR   RefSeq; WP_004687568.1; NZ_KN046805.1.
DR   AlphaFoldDB; Q9RPY4; -.
DR   CAZy; GH23; Glycoside Hydrolase Family 23.
DR   EnsemblBacteria; AEM19561; AEM19561; BS1330_II0069.
DR   GeneID; 45125488; -.
DR   GeneID; 55591806; -.
DR   KEGG; bms:BRA0069; -.
DR   KEGG; bsi:BS1330_II0069; -.
DR   PATRIC; fig|204722.21.peg.2301; -.
DR   HOGENOM; CLU_076837_0_0_5; -.
DR   OMA; TNFRHYG; -.
DR   PRO; PR:Q9RPY4; -.
DR   Proteomes; UP000007104; Chromosome II.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   InterPro; IPR008258; Transglycosylase_SLT_dom_1.
DR   Pfam; PF01464; SLT; 1.
DR   SUPFAM; SSF53955; SSF53955; 1.
PE   2: Evidence at transcript level;
KW   Virulence.
FT   CHAIN           1..238
FT                   /note="Type IV secretion system protein virB1"
FT                   /id="PRO_0000289554"
FT   REGION          197..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   238 AA;  25200 MW;  A8CDE5C128DC61DD CRC64;
     MVPFLVLAQQ CAPTVAPQTM AAIVQVESGF NPYAIGVVGG RLVRQPVSLD EAITTAQSLE
     AKGWNFSLGI AQVNRYNLPK YGSTYAQAFD PCKNLKMGSK ILEDCYRRAI VKMPGQEQGA
     LRAAFSCYYA GNFTGGFKTK PGSPSYVQKV VASADVTTKP IAVVPMIRKT PDAAAAVAAP
     VKKRQPADRN SVLVDLHPSS QSMPATGAAN APVRLKTEQP ATTDAPPGKD NTDGVVVF