ID   VIRB2_BARQU             Reviewed;         104 AA.
AC   Q8KQC3; Q4L2R1; Q6FYW9;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Type IV secretion system protein virB2;
DE   Flags: Precursor;
GN   Name=virB2; OrderedLocusNames=BQ10530;
OS   Bartonella quintana (strain Toulouse) (Rochalimaea quintana).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=283165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Toulouse;
RA   Alsmark U.C.M., Frank A.C., Thollesson M., Andersson S.G.E.;
RT   "Evolution of type IV secretion systems in Bartonella: horizontal
RT   transmission and gene conversion.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC VR-358 / Fuller / CIP 107027;
RA   Kohlhorst D.E., Soni T., Baumstark B.R.;
RT   "Genes composing the virB operon of Bartonella quintana.";
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND POSSIBLE FUNCTION.
RC   STRAIN=Toulouse;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT   of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC   -!- FUNCTION: Component of the type IV secretion system VirB/VirD4 which
CC       could be a major virulence determinant for subversion of human
CC       endothelial cell (HEC) function. VirB2 seems to constitute the major
CC       pilus component.
CC   -!- SUBUNIT: Homooligomer (Potential). Interacts with the 17 kDa antigen
CC       protein that is encoded within the VirB locus (By similarity).
CC       {ECO:0000250, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the virB2 family. {ECO:0000305}.
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DR   EMBL; AY122055; AAM82235.1; -; Genomic_DNA.
DR   EMBL; AY216720; AAM43798.1; -; Genomic_DNA.
DR   EMBL; BX897700; CAF26520.1; -; Genomic_DNA.
DR   RefSeq; WP_011179724.1; NC_005955.1.
DR   AlphaFoldDB; Q8KQC3; -.
DR   STRING; 283165.BQ10530; -.
DR   EnsemblBacteria; CAF26520; CAF26520; BQ10530.
DR   KEGG; bqu:BQ10530; -.
DR   eggNOG; COG3838; Bacteria.
DR   HOGENOM; CLU_158657_0_0_5; -.
DR   OMA; VIAIAWM; -.
DR   OrthoDB; 1867574at2; -.
DR   Proteomes; UP000000597; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007039; TrbC/VirB2.
DR   Pfam; PF04956; TrbC; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Signal; Transmembrane; Transmembrane helix;
KW   Transport; Virulence.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..104
FT                   /note="Type IV secretion system protein virB2"
FT                   /id="PRO_0000281411"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   104 AA;  10738 MW;  BD16FD2E04AE64A6 CRC64;
     MTETISRNII FIVIVLLLTA LVVSNPSYAA NSASSLGNVD SVLQNIVTMM TGTTAKLIAI
     ICVAAVGIGW MSGFIDLRKA AYCILGIGIV FGAPTLVSTL MGSS