ID   VIRB2_BRUA2             Reviewed;         105 AA.
AC   Q2YIT6; Q57A15; Q7BMZ9;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Type IV secretion system protein virB2;
DE   Flags: Precursor;
GN   Name=virB2; OrderedLocusNames=BAB2_0067;
OS   Brucella abortus (strain 2308).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=359391;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, AND FUNCTION.
RX   PubMed=10940027; DOI=10.1128/jb.182.17.4849-4855.2000;
RA   Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.;
RT   "A homologue of an operon required for DNA transfer in Agrobacterium is
RT   required in Brucella abortus for virulence and intracellular
RT   multiplication.";
RL   J. Bacteriol. 182:4849-4855(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2308;
RX   PubMed=16299333; DOI=10.1128/iai.73.12.8353-8361.2005;
RA   Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A.,
RA   Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT   "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL   Infect. Immun. 73:8353-8361(2005).
CC   -!- FUNCTION: The virB operon is essential for intracellular survival and
CC       is not involved in the invasion process. Constitutes a major
CC       determinant of virulence in mice. {ECO:0000269|PubMed:10940027}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Transcription is turned on at the beginning of the
CC       stationary phase of vegetative growth.
CC   -!- SIMILARITY: Belongs to the PtlA family. {ECO:0000305}.
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DR   EMBL; AF226278; AAF73895.1; -; Genomic_DNA.
DR   EMBL; AM040265; CAJ12233.1; -; Genomic_DNA.
DR   RefSeq; WP_002967165.1; NZ_KN046823.1.
DR   AlphaFoldDB; Q2YIT6; -.
DR   STRING; 359391.BAB2_0067; -.
DR   EnsemblBacteria; CAJ12233; CAJ12233; BAB2_0067.
DR   GeneID; 45125487; -.
DR   GeneID; 55591805; -.
DR   KEGG; bmf:BAB2_0067; -.
DR   PATRIC; fig|359391.11.peg.2014; -.
DR   HOGENOM; CLU_155084_1_1_5; -.
DR   OMA; TIMIAWA; -.
DR   BioCyc; MetaCyc:BAB_RS26680-MON; -.
DR   PHI-base; PHI:7605; -.
DR   PRO; PR:Q2YIT6; -.
DR   Proteomes; UP000002719; Chromosome II.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007039; TrbC/VirB2.
DR   Pfam; PF04956; TrbC; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix; Virulence.
FT   SIGNAL          1..36
FT                   /evidence="ECO:0000255"
FT   CHAIN           37..105
FT                   /note="Type IV secretion system protein virB2"
FT                   /id="PRO_0000291449"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   105 AA;  11107 MW;  837E9B32EA02B120 CRC64;
     MKTASPSKKS LSRILPHLLL ALIVSIAAIE PNLAHANGGL DKVNTSMQKV LDLLSGVSIT
     IVTIAIIWSG YKMAFRHARF MDVVPVLGGA LVVGAAAEIA SYLLR