ID   VIRB3_BARQU             Reviewed;         103 AA.
AC   Q6FYW8; Q4L2R0; Q8KQC2;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Type IV secretion system protein virB3;
GN   Name=virB3; OrderedLocusNames=BQ10540;
OS   Bartonella quintana (strain Toulouse) (Rochalimaea quintana).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=283165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Toulouse;
RA   Alsmark U.C.M., Frank A.C., Thollesson M., Andersson S.G.E.;
RT   "Evolution of type IV secretion systems in Bartonella: horizontal
RT   transmission and gene conversion.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC VR-358 / Fuller / CIP 107027;
RA   Kohlhorst D.E., Soni T., Baumstark B.R.;
RT   "Genes composing the virB operon of Bartonella quintana.";
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND POSSIBLE FUNCTION.
RC   STRAIN=Toulouse;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT   of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC   -!- FUNCTION: Component of the type IV secretion system VirB/VirD4 which
CC       could be a major virulence determinant for subversion of human
CC       endothelial cell (HEC) function. VirB3 may play a role in stabilization
CC       of pilus structure.
CC   -!- SUBUNIT: Interacts with the 17 kDa antigen protein that is encoded
CC       within the VirB locus. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the virB3 family. {ECO:0000305}.
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DR   EMBL; AY122055; AAM82236.1; -; Genomic_DNA.
DR   EMBL; AY216720; AAM43799.2; -; Genomic_DNA.
DR   EMBL; BX897700; CAF26521.1; -; Genomic_DNA.
DR   RefSeq; WP_011179725.1; NC_005955.1.
DR   AlphaFoldDB; Q6FYW8; -.
DR   STRING; 283165.BQ10540; -.
DR   EnsemblBacteria; CAF26521; CAF26521; BQ10540.
DR   KEGG; bqu:BQ10540; -.
DR   eggNOG; COG3702; Bacteria.
DR   HOGENOM; CLU_158477_1_0_5; -.
DR   OMA; FAWLNTR; -.
DR   OrthoDB; 1730670at2; -.
DR   Proteomes; UP000000597; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007792; T4SS_VirB3/TrbD/AvhB.
DR   Pfam; PF05101; VirB3; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Transmembrane; Transmembrane helix;
KW   Transport; Virulence.
FT   CHAIN           1..103
FT                   /note="Type IV secretion system protein virB3"
FT                   /id="PRO_0000281410"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         103
FT                   /note="R -> RCQL (in strain: ATCC VR-358 /Fuller / CIP
FT                   107027)"
SQ   SEQUENCE   103 AA;  11686 MW;  ABE71B216FEDEA09 CRC64;
     MNEDTLFLAC TRPATFAGVT MEGMALNVMA TSILFILTSN FTMIGLGIGL HFVLREVTKY
     DHNQFRVLFA WLNTRGKQKN LTRWGGGSTS PLRLIRTYKE LNR