ID   VIRB4_BARQU             Reviewed;         784 AA.
AC   Q6FYW7; Q4L2Q9; Q8KRG3;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Type IV secretion system protein virB4;
GN   Name=virB4; OrderedLocusNames=BQ10550;
OS   Bartonella quintana (strain Toulouse) (Rochalimaea quintana).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=283165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Toulouse;
RA   Alsmark U.C.M., Frank A.C., Thollesson M., Andersson S.G.E.;
RT   "Evolution of type IV secretion systems in Bartonella: horizontal
RT   transmission and gene conversion.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC VR-358 / Fuller / CIP 107027;
RA   Kohlhorst D.E., Soni T., Baumstark B.R.;
RT   "Genes composing the virB operon of Bartonella quintana.";
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND POSSIBLE FUNCTION.
RC   STRAIN=Toulouse;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT   of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC   -!- FUNCTION: Component of the type IV secretion system VirB/VirD4 which
CC       could be a major virulence determinant for subversion of human
CC       endothelial cell (HEC) function. Altogether with virB11, may be
CC       implicated in providing the energy, via hydrolysis of ATP, for the
CC       assembly of secretion system and substrate transport.
CC   -!- SUBUNIT: Interacts with virB10. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TrbE/VirB4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN04487.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AY122055; AAM82237.1; -; Genomic_DNA.
DR   EMBL; AY216720; AAN04487.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; BX897700; CAF26522.1; -; Genomic_DNA.
DR   RefSeq; WP_011179726.1; NC_005955.1.
DR   AlphaFoldDB; Q6FYW7; -.
DR   SMR; Q6FYW7; -.
DR   STRING; 283165.BQ10550; -.
DR   PRIDE; Q6FYW7; -.
DR   EnsemblBacteria; CAF26522; CAF26522; BQ10550.
DR   KEGG; bqu:BQ10550; -.
DR   eggNOG; COG3451; Bacteria.
DR   HOGENOM; CLU_008341_3_0_5; -.
DR   OMA; HRDLNTL; -.
DR   OrthoDB; 182908at2; -.
DR   Proteomes; UP000000597; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR004346; CagE_TrbE_VirB.
DR   InterPro; IPR018145; CagE_TrbE_VirB_cntrl_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR043964; P-loop_TraG.
DR   Pfam; PF03135; CagE_TrbE_VirB; 1.
DR   Pfam; PF19044; P-loop_TraG; 2.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00929; VirB4_CagE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW   Nucleotide-binding; Transport; Virulence.
FT   CHAIN           1..784
FT                   /note="Type IV secretion system protein virB4"
FT                   /id="PRO_0000281413"
FT   BINDING         435..442
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   784 AA;  89485 MW;  5A3450E2B33373D4 CRC64;
     MSIMKRESLP EEYIPYIRHV NQHVIALNSR CLMTVMAVEG VNFDTADINH LNSLHNQLNT
     LLRNIADERV ALYSHIIRRR ETIYPESRFF SSFAATLDEK YKKKMVSQEL YRNDLFVSLL
     WNPTSGKTEQ LASFFQRLTK AKKTQSEPDM EAIRKIEELS QDLIQGLESY EARLLSVYAH
     EGILFSEQSE FLHQLVGGRR ERIPLTFGTI ASTIYSDRVI FGKEMIEIRH ESNERFVGMF
     GWKEYPSKTR PGMTDGLLTA PFEFILTQSF VFKSKAAARV IMGRKQNQMI NAADRASSQI
     DALDEALDDL ESNRFVLGEH HLSLAVFADQ PKTLVEYLSK ARAHLTNGGA VIAREDLGLE
     AAWWAQLPGN FSYRARSGAI TSRNFAALSP FHSFPIGKLE GNVWGAAVAL LKTQAGSPYY
     FNFHYGDLGN TFVCGPSGSG KTVIVNFLLA QLQKHNPTMV FFDKDQGAEI FVRAGGGKYK
     PLKNGQPTGI APLKGMEYTE KNKIFLRSWV LKLVTTEGQT VTEQERQDIA KAINSLESLP
     HAQRSLGALQ LFFDNTSKEG IAIRLQRWIK GNDLGWVFDN DQDDLNLDSQ FIGYDMTDFL
     DNEEIRRPLM MYLFNRILDL IDGRRIIIVI DEFWKALEDD SFKAFAQDRL KTIRKQNGMM
     LFATQSPKDA LNSTIAHTII EQCPTQIFFP NQKANYKDYV EDFKLTEREF ELIQSELSRE
     SRRFLIKQGQ NSVVAELNLR GMNDEIAILS GTTKNIELVN QIINDYGADP DTWLPIFHQR
     RENQ