ID   VIRB5_BRUA2             Reviewed;         238 AA.
AC   Q2YJ75; Q9KIS8;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Type IV secretion system protein virB5;
DE   Flags: Precursor;
GN   Name=virB5; OrderedLocusNames=BAB2_0064;
OS   Brucella abortus (strain 2308).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=359391;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, AND FUNCTION.
RX   PubMed=10940027; DOI=10.1128/jb.182.17.4849-4855.2000;
RA   Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.;
RT   "A homologue of an operon required for DNA transfer in Agrobacterium is
RT   required in Brucella abortus for virulence and intracellular
RT   multiplication.";
RL   J. Bacteriol. 182:4849-4855(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2308;
RX   PubMed=16299333; DOI=10.1128/iai.73.12.8353-8361.2005;
RA   Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A.,
RA   Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT   "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL   Infect. Immun. 73:8353-8361(2005).
CC   -!- FUNCTION: The virB operon is essential for intracellular survival and
CC       is not involved in the invasion process. Constitutes a major
CC       determinant of virulence in mice. {ECO:0000269|PubMed:10940027}.
CC   -!- MISCELLANEOUS: Transcription is turned on at the beginning of the
CC       stationary phase of vegetative growth.
CC   -!- SIMILARITY: Belongs to the virb5 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF226278; AAF73898.1; -; Genomic_DNA.
DR   EMBL; AM040265; CAJ12230.1; -; Genomic_DNA.
DR   RefSeq; WP_006077544.1; NZ_KN046823.1.
DR   AlphaFoldDB; Q2YJ75; -.
DR   SMR; Q2YJ75; -.
DR   IntAct; Q2YJ75; 2.
DR   STRING; 359391.BAB2_0064; -.
DR   PRIDE; Q2YJ75; -.
DR   EnsemblBacteria; CAJ12230; CAJ12230; BAB2_0064.
DR   GeneID; 3827978; -.
DR   KEGG; bmf:BAB2_0064; -.
DR   PATRIC; fig|359391.11.peg.2011; -.
DR   HOGENOM; CLU_096790_1_0_5; -.
DR   OMA; GIDQRIC; -.
DR   PhylomeDB; Q2YJ75; -.
DR   BioCyc; MetaCyc:BAB_RS26665-MON; -.
DR   PRO; PR:Q2YJ75; -.
DR   Proteomes; UP000002719; Chromosome II.
DR   Gene3D; 1.20.58.430; -; 1.
DR   InterPro; IPR014158; T4SS_VirB5.
DR   InterPro; IPR023220; T4SS_VirB5-domain.
DR   Pfam; PF07996; T4SS; 1.
DR   TIGRFAMs; TIGR02791; VirB5; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal; Virulence.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..238
FT                   /note="Type IV secretion system protein virB5"
FT                   /id="PRO_0000290176"
FT   REGION          219..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   238 AA;  26829 MW;  E10B3F9F3E75E02E CRC64;
     MKKIILSFAF ALTVTSTAHA QLPVTDAGSI AQNLANHLEQ MVKFAQQIEQ LKQQFEQQKM
     QFDALTGNRG LGDILRDPTL RSYLPHNWRD LYEAVMSGGY LAAAGETANL LRKSQVYDPC
     ASISDKDQRI ACEAKVVKPV QDKVMTSKAY DATDKRLQEI ESLMQEINKT GDPKAIAELQ
     GRIESENAMI QNEDTRLRLY QQMAEAQDKL LDERQHELDA KDNARRGYPQ PKALEAAY