ID   VIRB5_BRUSU             Reviewed;         238 AA.
AC   Q9RPY0; G0KER3; Q8FXK4;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Type IV secretion system protein virB5;
DE   Flags: Precursor;
GN   Name=virB5; OrderedLocusNames=BRA0065, BS1330_II0065;
OS   Brucella suis biovar 1 (strain 1330).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=204722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=10510235; DOI=10.1046/j.1365-2958.1999.01569.x;
RA   O'Callaghan D., Cazevieille C., Allardet-Servent A., Boschiroli M.L.,
RA   Bourg G., Foulongne V., Frutos P., Kulakov Y., Ramuz M.;
RT   "A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis
RT   Ptl type IV secretion systems is essential for intracellular survival of
RT   Brucella suis.";
RL   Mol. Microbiol. 33:1210-1220(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND EXPRESSION CONDITIONS.
RC   STRAIN=1330;
RX   PubMed=11830669; DOI=10.1073/pnas.032514299;
RA   Boschiroli M.L., Ouahrani-Bettache S., Foulongne V., Michaux-Charachon S.,
RA   Bourg G., Allardet-Servent A., Cazevieille C., Liautard J.P., Ramuz M.,
RA   O'Callaghan D.;
RT   "The Brucella suis virB operon is induced intracellularly in macrophages.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:1544-1549(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=12271122; DOI=10.1073/pnas.192319099;
RA   Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA   Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA   Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA   Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT   "The Brucella suis genome reveals fundamental similarities between animal
RT   and plant pathogens and symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=22038969; DOI=10.1128/jb.06181-11;
RA   Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT   "Revised genome sequence of Brucella suis 1330.";
RL   J. Bacteriol. 193:6410-6410(2011).
CC   -!- FUNCTION: The VirB system could be required for the establishment of
CC       the replication niche in the host.
CC   -!- INDUCTION: Specifically induced within macrophages by phagosome
CC       acidification. Induced at 37 degrees Celsius in minimal medium,
CC       suggesting that nutritional stress is a regulating signal.
CC   -!- MISCELLANEOUS: Transcription of the operon is maximal in early
CC       exponential phase.
CC   -!- SIMILARITY: Belongs to the virb5 family. {ECO:0000305}.
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DR   EMBL; AF141604; AAD56615.1; -; Genomic_DNA.
DR   EMBL; AE014292; AAN33277.1; -; Genomic_DNA.
DR   EMBL; CP002998; AEM19557.1; -; Genomic_DNA.
DR   RefSeq; WP_006191582.1; NZ_KN046805.1.
DR   AlphaFoldDB; Q9RPY0; -.
DR   SMR; Q9RPY0; -.
DR   EnsemblBacteria; AEM19557; AEM19557; BS1330_II0065.
DR   GeneID; 45053162; -.
DR   KEGG; bms:BRA0065; -.
DR   KEGG; bsi:BS1330_II0065; -.
DR   PATRIC; fig|204722.21.peg.2305; -.
DR   HOGENOM; CLU_096790_1_0_5; -.
DR   OMA; GIDQRIC; -.
DR   PhylomeDB; Q9RPY0; -.
DR   PRO; PR:Q9RPY0; -.
DR   Proteomes; UP000007104; Chromosome II.
DR   Gene3D; 1.20.58.430; -; 1.
DR   InterPro; IPR014158; T4SS_VirB5.
DR   InterPro; IPR023220; T4SS_VirB5-domain.
DR   Pfam; PF07996; T4SS; 1.
DR   TIGRFAMs; TIGR02791; VirB5; 1.
PE   2: Evidence at transcript level;
KW   Signal; Virulence.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..238
FT                   /note="Type IV secretion system protein virB5"
FT                   /id="PRO_0000290179"
FT   REGION          219..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        108
FT                   /note="A -> T (in Ref. 1; AAD56615)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   238 AA;  26860 MW;  F8C3A41055214CC1 CRC64;
     MKKIILSFAF ALTVTSTAHA QLPVTDAGSI AQNLANHLEQ MVKFAQQIEQ LKQQFEEQKM
     QFDALTGYRG LGDILRDPTL RSYLPHNWRD LYEAVMSGGY LAAAGETANL LRKSQVYDPC
     ASISDKDQRI ACEAKVVKPV QDKVMTSKAY DATDKRLQEI ESLMQEINKT GDPKAIAELQ
     GRIESENAMI QNEDTRLHLY QQMAEAQDKL LDERQHELDA KDNARRGYPQ PKALEAAY