CAJ1_YEAST
ID CAJ1_YEAST Reviewed; 391 AA.
AC P39101; D3DLU9;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Protein CAJ1;
GN Name=CAJ1; OrderedLocusNames=YER048C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ATCC 204626 / S288c / A364A;
RX PubMed=8045411; DOI=10.1016/0378-1119(94)90334-4;
RA Mukai H., Shuntoh H., Chang C.-D., Asami M., Ueno M., Suzuki K., Kuno T.;
RT "Isolation and characterization of CAJ1, a novel yeast homolog of dnaJ.";
RL Gene 145:125-127(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169868;
RA Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA Botstein D., Davis R.W.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL Nature 387:78-81(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
RN [5]
RP UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-132, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22106047; DOI=10.1002/pmic.201100166;
RA Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.;
RT "Sites of ubiquitin attachment in Saccharomyces cerevisiae.";
RL Proteomics 12:236-240(2012).
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DR EMBL; D21164; BAA04700.1; -; mRNA.
DR EMBL; U18796; AAB64583.1; -; Genomic_DNA.
DR EMBL; BK006939; DAA07703.1; -; Genomic_DNA.
DR PIR; S48085; S48085.
DR RefSeq; NP_010967.3; NM_001178939.3.
DR AlphaFoldDB; P39101; -.
DR SMR; P39101; -.
DR BioGRID; 36785; 295.
DR DIP; DIP-5333N; -.
DR IntAct; P39101; 8.
DR MINT; P39101; -.
DR STRING; 4932.YER048C; -.
DR iPTMnet; P39101; -.
DR MaxQB; P39101; -.
DR PaxDb; P39101; -.
DR PRIDE; P39101; -.
DR EnsemblFungi; YER048C_mRNA; YER048C; YER048C.
DR GeneID; 856772; -.
DR KEGG; sce:YER048C; -.
DR SGD; S000000850; CAJ1.
DR VEuPathDB; FungiDB:YER048C; -.
DR eggNOG; KOG0691; Eukaryota.
DR GeneTree; ENSGT00940000176532; -.
DR HOGENOM; CLU_025145_3_1_1; -.
DR InParanoid; P39101; -.
DR OMA; DMKIESF; -.
DR BioCyc; YEAST:G3O-30227-MON; -.
DR PRO; PR:P39101; -.
DR Proteomes; UP000002311; Chromosome V.
DR RNAct; P39101; protein.
DR GO; GO:0005829; C:cytosol; IDA:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0005886; C:plasma membrane; IDA:SGD.
DR GO; GO:0006457; P:protein folding; ISS:SGD.
DR GO; GO:0016558; P:protein import into peroxisome matrix; IBA:GO_Central.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR026894; DnaJ_X.
DR InterPro; IPR036869; J_dom_sf.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF14308; DnaJ-X; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 1: Evidence at protein level;
KW Chaperone; Isopeptide bond; Reference proteome; Ubl conjugation.
FT CHAIN 1..391
FT /note="Protein CAJ1"
FT /id="PRO_0000071119"
FT DOMAIN 4..73
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT REGION 119..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 132
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0007744|PubMed:22106047"
SQ SEQUENCE 391 AA; 44855 MW; A295C96BA99542B1 CRC64;
MVKETEYYDI LGIKPEATPT EIKKAYRRKA METHPDKHPD DPDAQAKFQA VGEAYQVLSD
PGLRSKYDQF GKEDAVPQQG FEDASEYFTA IFGGDGFKDW IGEFSLFKEL NEATEMFGKE
DEEGTAATET EKADESTDGG MVKHDTNKAE SLKKDKLSKE QREKLMEMEK KRREDMMKQV
DELAEKLNEK ISRYLIAVKS NNLEEFTRKL DQEIEDLKLE SFGLELLYLL ARVYKTKANN
FIMSKKTYGI SKIFTGTRDN ARSVKSAYNL LSTGLEAQKA MEKMSEVNTD ELDQYERAKF
ESTMAGKALG VMWAMSKFEL ERKLKDVCNK ILNDKKVPSK ERIAKAKAML FIAHKFASAR
RSPEEAEEAR VFEELILGEQ EKEHKKHTVA R
