VIRB6_BARHE
ID VIRB6_BARHE Reviewed; 321 AA.
AC Q9RND2;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Type IV secretion system protein VirB6;
GN Name=virB6; OrderedLocusNames=BH13300;
OS Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)
OS (Rochalimaea henselae).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Bartonellaceae; Bartonella.
OX NCBI_TaxID=283166;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 49882 / DSM 28221 / Houston 1;
RX PubMed=10882236; DOI=10.1089/10445490050043344;
RA Padmalayam I., Karem K., Baumstark B.R., Massung R.;
RT "The gene encoding the 17-kDa antigen of Bartonella henselae is located
RT within a cluster of genes homologous to the virB virulence operon.";
RL DNA Cell Biol. 19:377-382(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49882 / DSM 28221 / Houston 1;
RX PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA La Scola B., Holmberg M., Andersson S.G.E.;
RT "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT of the zoonotic agent Bartonella henselae.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
RN [3]
RP INDUCTION.
RC STRAIN=ATCC 49882 / DSM 28221 / Houston 1;
RX PubMed=11553594; DOI=10.1128/iai.69.10.6495-6502.2001;
RA Schmiederer M., Arcenas R., Widen R., Valkov N., Anderson B.E.;
RT "Intracellular induction of the Bartonella henselae virB operon by human
RT endothelial cells.";
RL Infect. Immun. 69:6495-6502(2001).
RN [4]
RP FUNCTION.
RC STRAIN=ATCC 49882 / DSM 28221 / Houston 1;
RX PubMed=15049812; DOI=10.1111/j.1365-2958.2003.03964.x;
RA Schmid M.C., Schulein R., Dehio M., Denecker G., Carena I., Dehio C.;
RT "The VirB type IV secretion system of Bartonella henselae mediates
RT invasion, proinflammatory activation and antiapoptotic protection of
RT endothelial cells.";
RL Mol. Microbiol. 52:81-92(2004).
RN [5]
RP FUNCTION.
RC STRAIN=ATCC 49882 / DSM 28221 / Houston 1;
RX PubMed=15642951; DOI=10.1073/pnas.0406796102;
RA Schulein R., Guye P., Rhomberg T.A., Schmid M.C., Schroeder G.,
RA Vergunst A.C., Carena I., Dehio C.;
RT "A bipartite signal mediates the transfer of type IV secretion substrates
RT of Bartonella henselae into human cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:856-861(2005).
CC -!- FUNCTION: The type IV secretion system VirB/VirD4 is a major virulence
CC determinant for subversion of human endothelial cell (HEC) function.
CC VirB-dependent changes of HEC include massive cytoskeletal
CC rearrangements, a pro-inflammatory activation by nuclear factor NF-
CC kappa-B, inhibition of early and late events of apoptosis, leading to
CC an increased cell survival, and, at high infection doses, a cytostatic
CC or cytotoxic effect, which interfers with a potent VirB-independent
CC mitogenic activity. These changes of HEC require the T4S coupling
CC protein VirD4 and at least one of the effector proteins BepA-G.
CC {ECO:0000269|PubMed:15049812, ECO:0000269|PubMed:15642951}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- INDUCTION: During the interaction with the intracellular environment of
CC host cells. {ECO:0000269|PubMed:11553594}.
CC -!- SIMILARITY: Belongs to the TrbL/VirB6 family. {ECO:0000305}.
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DR EMBL; AF182718; AAF00944.1; -; Genomic_DNA.
DR EMBL; BX897699; CAF28103.1; -; Genomic_DNA.
DR RefSeq; WP_011181131.1; NZ_LRIJ02000001.1.
DR AlphaFoldDB; Q9RND2; -.
DR STRING; 283166.BH13300; -.
DR PaxDb; Q9RND2; -.
DR EnsemblBacteria; CAF28103; CAF28103; BH13300.
DR GeneID; 64157500; -.
DR KEGG; bhe:BH13300; -.
DR eggNOG; COG3704; Bacteria.
DR OMA; FIVQMFA; -.
DR Proteomes; UP000000421; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030255; P:protein secretion by the type IV secretion system; IEA:InterPro.
DR InterPro; IPR007688; Conjugal_tfr_TrbL/VirB6.
DR Pfam; PF04610; TrbL; 1.
PE 2: Evidence at transcript level;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport; Virulence.
FT CHAIN 1..321
FT /note="Type IV secretion system protein VirB6"
FT /id="PRO_0000273530"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 321 AA; 34083 MW; E40AB18EA8743577 CRC64;
MSDFSFSPFE SISGYILQPL NNVMNTTVSG LSSAISAPLN LASIIFIFLY GYNVMTGRVA
LSMNSLLNNV VKIVIVTTMA TNADTFNTYV KNIFFGDLAN AIGNALNSNP SSANVFDYIL
LKTSARYQEV LAAAWFLEKI MVGLLGSLMI MAVIVFCIGG FIVQMFAQVA LVMIIGLGPL
FISLYLFNAT RKFTDAWITT LVNFTILQVL VIMLGTIMCK IILYVLDGTY ESIYFLFPPV
VVISIVGAIL FRALPGIASA LSSGGPYFNA GISSGGQIFT MLSSGAKTGR NAAKSAASTL
SGAAGTATKA AKIGGNGRGR F
