ID   VIRB6_BARQU             Reviewed;         321 AA.
AC   Q6FYW5; Q4L2Q7; Q8KPE7;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Type IV secretion system protein VirB6;
GN   Name=virB6; OrderedLocusNames=BQ10570;
OS   Bartonella quintana (strain Toulouse) (Rochalimaea quintana).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=283165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Toulouse;
RA   Alsmark U.C.M., Frank A.C., Thollesson M., Andersson S.G.E.;
RT   "Evolution of type IV secretion systems in Bartonella: horizontal
RT   transmission and gene conversion.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC VR-358 / Fuller / CIP 107027;
RA   Kohlhorst D.E., Soni T., Baumstark B.R.;
RT   "Genes composing the virB operon of Bartonella quintana.";
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND POSSIBLE FUNCTION.
RC   STRAIN=Toulouse;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT   of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC   -!- FUNCTION: Component of the type IV secretion system VirB/VirD4 which
CC       could be a major virulence determinant for subversion of human
CC       endothelial cell (HEC) function.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TrbL/VirB6 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM82168.2; Type=Frameshift; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY122055; AAM82239.1; -; Genomic_DNA.
DR   EMBL; AY216720; AAM82168.2; ALT_FRAME; Genomic_DNA.
DR   EMBL; BX897700; CAF26524.1; -; Genomic_DNA.
DR   RefSeq; WP_011179728.1; NC_005955.1.
DR   AlphaFoldDB; Q6FYW5; -.
DR   STRING; 283165.BQ10570; -.
DR   EnsemblBacteria; CAF26524; CAF26524; BQ10570.
DR   GeneID; 56533401; -.
DR   KEGG; bqu:BQ10570; -.
DR   eggNOG; COG3704; Bacteria.
DR   HOGENOM; CLU_065797_1_0_5; -.
DR   OMA; FIVQMFA; -.
DR   OrthoDB; 1488773at2; -.
DR   Proteomes; UP000000597; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030255; P:protein secretion by the type IV secretion system; IEA:InterPro.
DR   InterPro; IPR007688; Conjugal_tfr_TrbL/VirB6.
DR   Pfam; PF04610; TrbL; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..321
FT                   /note="Type IV secretion system protein VirB6"
FT                   /id="PRO_0000281415"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         4
FT                   /note="F -> FSFSP (in strain: ATCC VR-358 / Fuller / CIP
FT                   107027)"
SQ   SEQUENCE   321 AA;  34107 MW;  1BD5429C68A806D2 CRC64;
     MSDFSFSPFE SISGYILNPL ENAMNTTVSG LSSAISAPLN LASIIFIFLY GYNVMTGRVS
     LSMHSLLNNV VKIVVVTAMA TNADTFNTYV KDIFFGDLAN AIGNALNSNP ASANVFDYIL
     LKTSARYQEV LAAAWFLEKI MVGLLGSLMI MAVIVFCIGG FIVQMFAQVA LVMIIGLGPL
     FISLYLFNAT RKFTDAWITT LINFTILQVL VIMLGTIMCK IILHVLNGTY DSIYFLFPPV
     VVISIVGAIL FRALPGIASA LSSGGPYFNA GISSGGQIFT MLSSGAKTGR NAAKSAASTL
     SGTAGAAAKV AKIGDRGRGR F