ID   VIRB6_BRUA2             Reviewed;         347 AA.
AC   Q2YJ76; Q57A19; Q9KIS7;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Type IV secretion system protein VirB6;
GN   Name=virB6; OrderedLocusNames=BAB2_0063;
OS   Brucella abortus (strain 2308).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=359391;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, AND FUNCTION.
RX   PubMed=10940027; DOI=10.1128/jb.182.17.4849-4855.2000;
RA   Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.;
RT   "A homologue of an operon required for DNA transfer in Agrobacterium is
RT   required in Brucella abortus for virulence and intracellular
RT   multiplication.";
RL   J. Bacteriol. 182:4849-4855(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2308;
RX   PubMed=16299333; DOI=10.1128/iai.73.12.8353-8361.2005;
RA   Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A.,
RA   Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT   "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL   Infect. Immun. 73:8353-8361(2005).
CC   -!- FUNCTION: The virB operon is essential for intracellular survival and
CC       is not involved in the invasion process. Constitutes a major
CC       determinant of virulence in mice. {ECO:0000269|PubMed:10940027}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Transcription is turned on at the beginning of the
CC       stationary phase of vegetative growth.
CC   -!- SIMILARITY: Belongs to the TrbL/VirB6 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF226278; AAF73899.1; -; Genomic_DNA.
DR   EMBL; AM040265; CAJ12229.1; -; Genomic_DNA.
DR   RefSeq; WP_002969266.1; NZ_KN046823.1.
DR   AlphaFoldDB; Q2YJ76; -.
DR   STRING; 359391.BAB2_0063; -.
DR   EnsemblBacteria; CAJ12229; CAJ12229; BAB2_0063.
DR   GeneID; 45125483; -.
DR   GeneID; 55591801; -.
DR   KEGG; bmf:BAB2_0063; -.
DR   PATRIC; fig|359391.11.peg.2010; -.
DR   HOGENOM; CLU_065797_0_0_5; -.
DR   OMA; FIVQMFA; -.
DR   PhylomeDB; Q2YJ76; -.
DR   BioCyc; MetaCyc:BAB_RS26660-MON; -.
DR   Proteomes; UP000002719; Chromosome II.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030255; P:protein secretion by the type IV secretion system; IEA:InterPro.
DR   InterPro; IPR007688; Conjugal_tfr_TrbL/VirB6.
DR   Pfam; PF04610; TrbL; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..347
FT                   /note="Type IV secretion system protein VirB6"
FT                   /id="PRO_0000290180"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   347 AA;  36134 MW;  DDAFBAC037970F52 CRC64;
     MVNPVIFEFI GTSIHNQLNN YVTMVASNTM NMIATTAVLA GGLYYTAMGI LMSVGRIEGP
     FSQLVISCIK FMLIAAFALN ISTYSEWVID TVHNMESGFA DAFAGNHGTP SSTIYQTLDN
     SLGKGWNIAA MLFEKGDNRG LTQIVQGFSE LLLSFLVAGS TLILAGPTGA MIVATNAVIA
     ILLGIGPLFI LALGWAPTRG FFDRWFGAIV TSILQVALLS AVLSISSAIF SRMVAAINLA
     SATQSTLFSC LSLTAVTIVM PYMMYKVYEY GGILGSSISA ATISLGSLAV NTATSGGGAM
     TSIFSGSSGG GGSGSAKAGG ESSYSAGGNA MWSPAYRQHV LGQFNRD