ID   VIRB7_BRUA2             Reviewed;          57 AA.
AC   Q2YJ77; Q57A20; Q7BMZ7;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Type IV secretion system putative lipoprotein virB7;
DE   Flags: Precursor;
GN   Name=virB7; OrderedLocusNames=BAB2_0062;
OS   Brucella abortus (strain 2308).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=359391;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, AND FUNCTION.
RX   PubMed=10940027; DOI=10.1128/jb.182.17.4849-4855.2000;
RA   Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.;
RT   "A homologue of an operon required for DNA transfer in Agrobacterium is
RT   required in Brucella abortus for virulence and intracellular
RT   multiplication.";
RL   J. Bacteriol. 182:4849-4855(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2308;
RX   PubMed=16299333; DOI=10.1128/iai.73.12.8353-8361.2005;
RA   Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A.,
RA   Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT   "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL   Infect. Immun. 73:8353-8361(2005).
CC   -!- FUNCTION: The virB operon is essential for intracellular survival and
CC       is not involved in the invasion process. Constitutes a major
CC       determinant of virulence in mice. {ECO:0000269|PubMed:10940027}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- MISCELLANEOUS: Transcription is turned on at the beginning of the
CC       stationary phase of vegetative growth.
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DR   EMBL; AF226278; AAF73900.1; -; Genomic_DNA.
DR   EMBL; AM040265; CAJ12228.1; -; Genomic_DNA.
DR   RefSeq; WP_002966516.1; NZ_KN046823.1.
DR   AlphaFoldDB; Q2YJ77; -.
DR   EnsemblBacteria; CAJ12228; CAJ12228; BAB2_0062.
DR   GeneID; 45125482; -.
DR   GeneID; 55591800; -.
DR   KEGG; bmf:BAB2_0062; -.
DR   HOGENOM; CLU_211045_0_0_5; -.
DR   OMA; QCITLLC; -.
DR   BioCyc; MetaCyc:BAB_RS26655-MON; -.
DR   Proteomes; UP000002719; Chromosome II.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR012640; Membr_lipoprot_lipid_attach_CS.
DR   Pfam; PF08139; LPAM_1; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal; Virulence.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           17..57
FT                   /note="Type IV secretion system putative lipoprotein virB7"
FT                   /id="PRO_0000291440"
FT   REGION          35..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           17
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           17
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   57 AA;  5931 MW;  4E547B72CEF445E3 CRC64;
     MKKVILAFVA TAFLAGCTTT GPAVVPVLDG KPRVPVNKSV PAKPPLAQPN PVDTYED