VIRB7_BRUSU
ID VIRB7_BRUSU Reviewed; 57 AA.
AC Q7CEG2; G0KER1; Q7BQL5;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Type IV secretion system putative lipoprotein virB7;
DE Flags: Precursor;
GN Name=virB7; OrderedLocusNames=BRA0063, BS1330_II0063;
OS Brucella suis biovar 1 (strain 1330).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=204722;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=1330;
RX PubMed=10510235; DOI=10.1046/j.1365-2958.1999.01569.x;
RA O'Callaghan D., Cazevieille C., Allardet-Servent A., Boschiroli M.L.,
RA Bourg G., Foulongne V., Frutos P., Kulakov Y., Ramuz M.;
RT "A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis
RT Ptl type IV secretion systems is essential for intracellular survival of
RT Brucella suis.";
RL Mol. Microbiol. 33:1210-1220(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND EXPRESSION CONDITIONS.
RC STRAIN=1330;
RX PubMed=11830669; DOI=10.1073/pnas.032514299;
RA Boschiroli M.L., Ouahrani-Bettache S., Foulongne V., Michaux-Charachon S.,
RA Bourg G., Allardet-Servent A., Cazevieille C., Liautard J.P., Ramuz M.,
RA O'Callaghan D.;
RT "The Brucella suis virB operon is induced intracellularly in macrophages.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:1544-1549(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1330;
RX PubMed=12271122; DOI=10.1073/pnas.192319099;
RA Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT "The Brucella suis genome reveals fundamental similarities between animal
RT and plant pathogens and symbionts.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1330;
RX PubMed=22038969; DOI=10.1128/jb.06181-11;
RA Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT "Revised genome sequence of Brucella suis 1330.";
RL J. Bacteriol. 193:6410-6410(2011).
CC -!- FUNCTION: The VirB system could be required for the establishment of
CC the replication niche in the host.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC -!- INDUCTION: Specifically induced within macrophages by phagosome
CC acidification. Induced at 37 degrees Celsius in minimal medium,
CC suggesting that nutritional stress is a regulating signal.
CC -!- MISCELLANEOUS: Transcription of the operon is maximal in early
CC exponential phase.
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DR EMBL; AF141604; AAD56617.1; -; Genomic_DNA.
DR EMBL; AE014292; AAN33275.1; -; Genomic_DNA.
DR EMBL; CP002998; AEM19555.1; -; Genomic_DNA.
DR RefSeq; WP_002966516.1; NZ_KN046805.1.
DR AlphaFoldDB; Q7CEG2; -.
DR EnsemblBacteria; AEM19555; AEM19555; BS1330_II0063.
DR GeneID; 45125482; -.
DR GeneID; 55591800; -.
DR KEGG; bms:BRA0063; -.
DR KEGG; bsi:BS1330_II0063; -.
DR PATRIC; fig|204722.21.peg.2307; -.
DR HOGENOM; CLU_211045_0_0_5; -.
DR OMA; QCITLLC; -.
DR Proteomes; UP000007104; Chromosome II.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR012640; Membr_lipoprot_lipid_attach_CS.
DR Pfam; PF08139; LPAM_1; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Lipoprotein; Membrane; Palmitate; Signal; Virulence.
FT SIGNAL 1..16
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 17..57
FT /note="Type IV secretion system putative lipoprotein virB7"
FT /id="PRO_0000291444"
FT REGION 35..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 17
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT LIPID 17
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ SEQUENCE 57 AA; 5931 MW; 4E547B72CEF445E3 CRC64;
MKKVILAFVA TAFLAGCTTT GPAVVPVLDG KPRVPVNKSV PAKPPLAQPN PVDTYED