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VIRB9_BARHE
ID   VIRB9_BARHE             Reviewed;         288 AA.
AC   Q6G2B3; Q9RNC9;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Type IV secretion system protein virB9;
DE   Flags: Precursor;
GN   Name=virB9; OrderedLocusNames=BH13330;
OS   Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)
OS   (Rochalimaea henselae).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=283166;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 49882 / DSM 28221 / Houston 1;
RX   PubMed=10882236; DOI=10.1089/10445490050043344;
RA   Padmalayam I., Karem K., Baumstark B.R., Massung R.;
RT   "The gene encoding the 17-kDa antigen of Bartonella henselae is located
RT   within a cluster of genes homologous to the virB virulence operon.";
RL   DNA Cell Biol. 19:377-382(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49882 / DSM 28221 / Houston 1;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT   of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
RN   [3]
RP   INDUCTION.
RC   STRAIN=ATCC 49882 / DSM 28221 / Houston 1;
RX   PubMed=11553594; DOI=10.1128/iai.69.10.6495-6502.2001;
RA   Schmiederer M., Arcenas R., Widen R., Valkov N., Anderson B.E.;
RT   "Intracellular induction of the Bartonella henselae virB operon by human
RT   endothelial cells.";
RL   Infect. Immun. 69:6495-6502(2001).
RN   [4]
RP   INTERACTION WITH 15 KDA PROTEIN; VIRB8; VIRB10 AND VIRB11.
RX   PubMed=15231811; DOI=10.1128/jb.186.14.4796-4801.2004;
RA   Shamaei-Tousi A., Cahill R., Frankel G.;
RT   "Interaction between protein subunits of the type IV secretion system of
RT   Bartonella henselae.";
RL   J. Bacteriol. 186:4796-4801(2004).
RN   [5]
RP   FUNCTION.
RC   STRAIN=ATCC 49882 / DSM 28221 / Houston 1;
RX   PubMed=15049812; DOI=10.1111/j.1365-2958.2003.03964.x;
RA   Schmid M.C., Schulein R., Dehio M., Denecker G., Carena I., Dehio C.;
RT   "The VirB type IV secretion system of Bartonella henselae mediates
RT   invasion, proinflammatory activation and antiapoptotic protection of
RT   endothelial cells.";
RL   Mol. Microbiol. 52:81-92(2004).
RN   [6]
RP   FUNCTION.
RC   STRAIN=ATCC 49882 / DSM 28221 / Houston 1;
RX   PubMed=15642951; DOI=10.1073/pnas.0406796102;
RA   Schulein R., Guye P., Rhomberg T.A., Schmid M.C., Schroeder G.,
RA   Vergunst A.C., Carena I., Dehio C.;
RT   "A bipartite signal mediates the transfer of type IV secretion substrates
RT   of Bartonella henselae into human cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:856-861(2005).
CC   -!- FUNCTION: The type IV secretion system VirB/VirD4 is a major virulence
CC       determinant for subversion of human endothelial cell (HEC) function.
CC       VirB-dependent changes of HEC include massive cytoskeletal
CC       rearrangements, a pro-inflammatory activation by nuclear factor NF-
CC       kappa-B, inhibition of early and late events of apoptosis, leading to
CC       an increased cell survival, and, at high infection doses, a cytostatic
CC       or cytotoxic effect, which interfers with a potent VirB-independent
CC       mitogenic activity. These changes of HEC require the T4S coupling
CC       protein VirD4 and at least one of the effector proteins BepA-G.
CC       {ECO:0000269|PubMed:15049812, ECO:0000269|PubMed:15642951}.
CC   -!- SUBUNIT: Interacts with virB8, virB10, virB11 and the 15 kDa protein
CC       that is encoded within the VirB locus. {ECO:0000269|PubMed:15231811}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- INDUCTION: During the interaction with the intracellular environment of
CC       host cells. {ECO:0000269|PubMed:11553594}.
CC   -!- SIMILARITY: Belongs to the TrbG/VirB9 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAF28106.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF182718; AAF00947.1; -; Genomic_DNA.
DR   EMBL; BX897699; CAF28106.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_034448090.1; NZ_LRIJ02000001.1.
DR   AlphaFoldDB; Q6G2B3; -.
DR   SMR; Q6G2B3; -.
DR   STRING; 283166.BH13330; -.
DR   PaxDb; Q6G2B3; -.
DR   PRIDE; Q6G2B3; -.
DR   EnsemblBacteria; CAF28106; CAF28106; BH13330.
DR   KEGG; bhe:BH13330; -.
DR   eggNOG; COG3504; Bacteria.
DR   Proteomes; UP000000421; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   CDD; cd06911; VirB9_CagX_TrbG; 1.
DR   Gene3D; 2.60.40.2500; -; 1.
DR   InterPro; IPR010258; Conjugal_tfr_TrbG/VirB9/CagX.
DR   InterPro; IPR014148; VirB9.
DR   InterPro; IPR033645; VirB9/CagX/TrbG_C.
DR   InterPro; IPR038161; VirB9/CagX/TrbG_C_sf.
DR   Pfam; PF03524; CagX; 1.
DR   TIGRFAMs; TIGR02781; VirB9; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   Periplasm; Signal; Transport; Virulence.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           26..288
FT                   /note="Type IV secretion system protein virB9"
FT                   /id="PRO_0000273534"
FT   REGION          267..288
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        267..281
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   288 AA;  32120 MW;  B94F15C58F38D489 CRC64;
     MMRILKTLFL AFIAAISCYT TPSFAETAPV SARKDNRIRF VNYDPYNVTK IIGSIRSSVQ
     LEFADDEEVT YVGIGNSVAW QVAPAGHFVF LKPREVQPVT NLQIVTSRQD GTKRSYQFEL
     QVREGDVSAG NDTYFLVKFR YPEDEALRKK LAEAAKAAQR EENFVNDIFN THEDFGPRNW
     AYEAQGSPLI EPASVYDNGK TTTFTFLGNT EIPAIYLVSL DGQEALVPKT IKGNKVIVHA
     TAAQFTLRRG NDVLCIFNKR FVPAGVNPET GTTSPSVQRK VNIGNGYE
 
 
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