ID   VIRB9_BARQU             Reviewed;         289 AA.
AC   Q6FYW2; Q4L2Q4; Q84BW5;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 2.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Type IV secretion system protein virB9;
DE   Flags: Precursor;
GN   Name=virB9; OrderedLocusNames=BQ10600;
OS   Bartonella quintana (strain Toulouse) (Rochalimaea quintana).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=283165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Toulouse;
RA   Alsmark U.C.M., Frank A.C., Thollesson M., Andersson S.G.E.;
RT   "Evolution of type IV secretion systems in Bartonella: horizontal
RT   transmission and gene conversion.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC VR-358 / Fuller / CIP 107027;
RA   Kohlhorst D.E., Soni T., Baumstark B.R.;
RT   "Genes composing the virB operon of Bartonella quintana.";
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND POSSIBLE FUNCTION.
RC   STRAIN=Toulouse;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT   of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC   -!- FUNCTION: Component of the type IV secretion system VirB/VirD4 which
CC       could be a major virulence determinant for subversion of human
CC       endothelial cell (HEC) function.
CC   -!- SUBUNIT: Interacts with virB8, virB10, virB11 and the 15 kDa protein
CC       that is encoded within the VirB locus. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TrbG/VirB9 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAF26527.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY122055; AAM82242.1; -; Genomic_DNA.
DR   EMBL; AY216720; AAO85707.1; -; Genomic_DNA.
DR   EMBL; BX897700; CAF26527.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_034450092.1; NC_005955.1.
DR   AlphaFoldDB; Q6FYW2; -.
DR   SMR; Q6FYW2; -.
DR   STRING; 283165.BQ10600; -.
DR   EnsemblBacteria; CAF26527; CAF26527; BQ10600.
DR   KEGG; bqu:BQ10600; -.
DR   eggNOG; COG3504; Bacteria.
DR   HOGENOM; CLU_058585_3_0_5; -.
DR   OMA; FGPRNWA; -.
DR   OrthoDB; 1251301at2; -.
DR   Proteomes; UP000000597; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   CDD; cd06911; VirB9_CagX_TrbG; 1.
DR   Gene3D; 2.60.40.2500; -; 1.
DR   InterPro; IPR010258; Conjugal_tfr_TrbG/VirB9/CagX.
DR   InterPro; IPR014148; VirB9.
DR   InterPro; IPR033645; VirB9/CagX/TrbG_C.
DR   InterPro; IPR038161; VirB9/CagX/TrbG_C_sf.
DR   Pfam; PF03524; CagX; 1.
DR   TIGRFAMs; TIGR02781; VirB9; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Periplasm; Signal; Transport; Virulence.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           26..289
FT                   /note="Type IV secretion system protein virB9"
FT                   /id="PRO_0000281416"
FT   REGION          267..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        267..281
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         121..133
FT                   /note="QVREGDVSAGNDT -> KFVKATFHRRY (in strain: ATCC VR-358
FT                   / Fuller / CIP 107027)"
FT   VARIANT         138..149
FT                   /note="KFRYPEDEALRK -> SFVIQKNFAQ (in strain: ATCC VR-358 /
FT                   Fuller / CIP 107027)"
SQ   SEQUENCE   289 AA;  32323 MW;  647FF254C93C1DFD CRC64;
     MMRFSKIIFL AFLFAISCLT VPLFAETAPV SARKDNRIRF VNYDPYNVTQ IIGSIRSSVQ
     LEFADDEEVT YVGIGNSVAW QVAPAGHFVF LKPREVQPVT NLQIVTSRQD GTKRSYQFEL
     QVREGDVSAG NDTYFLVKFR YPEDEALRKK LAKAAEAAQR EENFVNDVFN IHENFGPRNW
     AYEAQGSSLI EPASVYDNGK TTTFTFLGNT EIPAIYLVSL DGQESLVPKS IKGNKVIVHA
     IAAQFTLRRG NDVLCIFNKR FVPEGINPET GTTSPSVQRR VNIGNGHEG