ID   VIRB9_BRUA2             Reviewed;         289 AA.
AC   Q2YJ79; Q57A22; Q7BMZ5;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Type IV secretion system protein virB9;
DE   Flags: Precursor;
GN   Name=virB9; OrderedLocusNames=BAB2_0060;
OS   Brucella abortus (strain 2308).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=359391;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, AND FUNCTION.
RX   PubMed=10940027; DOI=10.1128/jb.182.17.4849-4855.2000;
RA   Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.;
RT   "A homologue of an operon required for DNA transfer in Agrobacterium is
RT   required in Brucella abortus for virulence and intracellular
RT   multiplication.";
RL   J. Bacteriol. 182:4849-4855(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2308;
RX   PubMed=16299333; DOI=10.1128/iai.73.12.8353-8361.2005;
RA   Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A.,
RA   Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT   "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL   Infect. Immun. 73:8353-8361(2005).
CC   -!- FUNCTION: The virB operon is essential for intracellular survival and
CC       is not involved in the invasion process. Constitutes a major
CC       determinant of virulence in mice. {ECO:0000269|PubMed:10940027}.
CC   -!- MISCELLANEOUS: Transcription is turned on at the beginning of the
CC       stationary phase of vegetative growth.
CC   -!- SIMILARITY: Belongs to the TrbG/VirB9 family. {ECO:0000305}.
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DR   EMBL; AF226278; AAF73902.1; -; Genomic_DNA.
DR   EMBL; AM040265; CAJ12226.1; -; Genomic_DNA.
DR   RefSeq; WP_002966518.1; NZ_KN046823.1.
DR   AlphaFoldDB; Q2YJ79; -.
DR   SMR; Q2YJ79; -.
DR   STRING; 359391.BAB2_0060; -.
DR   EnsemblBacteria; CAJ12226; CAJ12226; BAB2_0060.
DR   GeneID; 45125480; -.
DR   GeneID; 55591798; -.
DR   KEGG; bmf:BAB2_0060; -.
DR   PATRIC; fig|359391.11.peg.2008; -.
DR   HOGENOM; CLU_058585_3_0_5; -.
DR   OMA; MPAIYIE; -.
DR   PhylomeDB; Q2YJ79; -.
DR   BioCyc; MetaCyc:BAB_RS26645-MON; -.
DR   Proteomes; UP000002719; Chromosome II.
DR   CDD; cd06911; VirB9_CagX_TrbG; 1.
DR   Gene3D; 2.60.40.2500; -; 1.
DR   InterPro; IPR010258; Conjugal_tfr_TrbG/VirB9/CagX.
DR   InterPro; IPR014148; VirB9.
DR   InterPro; IPR033645; VirB9/CagX/TrbG_C.
DR   InterPro; IPR038161; VirB9/CagX/TrbG_C_sf.
DR   Pfam; PF03524; CagX; 1.
DR   TIGRFAMs; TIGR02781; VirB9; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal; Virulence.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..289
FT                   /note="Type IV secretion system protein virB9"
FT                   /id="PRO_0000291432"
SQ   SEQUENCE   289 AA;  31951 MW;  666BE65C328BD91C CRC64;
     MKRFLLACIL ITLASPSWAT KIPSGSKYDS RIQYVDYNSG DVVLVRALPG VGARIVFAPG
     ENIEDVASGF TQGWEFKASH NILYLKARSM TLSHSNQSID MAPEPGKWDT NLMVTTDQRM
     YDFDLRLMPG RNNQRVAYRV QFRYPAAAAA AAVAAAQKRV VQARMNARPS PVNWNYTMQV
     GTNSASIAPT LAYDDGRFTY LRFPNNRDFP AAFLVAEDKS ESIVNSHIDP SAPDILVLHR
     VAKQMVLRLG NKVIGIYNES FNPDGVPARD GTTVPGVKRV IKSPGENLQ