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VIRB9_BRUSU
ID   VIRB9_BRUSU             Reviewed;         289 AA.
AC   Q9RPX6; G0KEQ9; Q7CEG4;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Type IV secretion system protein virB9;
DE   Flags: Precursor;
GN   Name=virB9; OrderedLocusNames=BRA0061, BS1330_II0061;
OS   Brucella suis biovar 1 (strain 1330).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=204722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=10510235; DOI=10.1046/j.1365-2958.1999.01569.x;
RA   O'Callaghan D., Cazevieille C., Allardet-Servent A., Boschiroli M.L.,
RA   Bourg G., Foulongne V., Frutos P., Kulakov Y., Ramuz M.;
RT   "A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis
RT   Ptl type IV secretion systems is essential for intracellular survival of
RT   Brucella suis.";
RL   Mol. Microbiol. 33:1210-1220(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND EXPRESSION CONDITIONS.
RC   STRAIN=1330;
RX   PubMed=11830669; DOI=10.1073/pnas.032514299;
RA   Boschiroli M.L., Ouahrani-Bettache S., Foulongne V., Michaux-Charachon S.,
RA   Bourg G., Allardet-Servent A., Cazevieille C., Liautard J.P., Ramuz M.,
RA   O'Callaghan D.;
RT   "The Brucella suis virB operon is induced intracellularly in macrophages.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:1544-1549(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=12271122; DOI=10.1073/pnas.192319099;
RA   Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA   Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA   Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA   Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT   "The Brucella suis genome reveals fundamental similarities between animal
RT   and plant pathogens and symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=22038969; DOI=10.1128/jb.06181-11;
RA   Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT   "Revised genome sequence of Brucella suis 1330.";
RL   J. Bacteriol. 193:6410-6410(2011).
CC   -!- FUNCTION: The VirB system could be required for the establishment of
CC       the replication niche in the host.
CC   -!- INDUCTION: Specifically induced within macrophages by phagosome
CC       acidification. Induced at 37 degrees Celsius in minimal medium,
CC       suggesting that nutritional stress is a regulating signal.
CC   -!- MISCELLANEOUS: Transcription of the operon is maximal in early
CC       exponential phase.
CC   -!- SIMILARITY: Belongs to the TrbG/VirB9 family. {ECO:0000305}.
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DR   EMBL; AF141604; AAD56619.1; -; Genomic_DNA.
DR   EMBL; AE014292; AAN33273.1; -; Genomic_DNA.
DR   EMBL; CP002998; AEM19553.1; -; Genomic_DNA.
DR   RefSeq; WP_002966518.1; NZ_KN046805.1.
DR   AlphaFoldDB; Q9RPX6; -.
DR   SMR; Q9RPX6; -.
DR   TCDB; 3.A.7.3.1; the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family.
DR   EnsemblBacteria; AEM19553; AEM19553; BS1330_II0061.
DR   GeneID; 45125480; -.
DR   GeneID; 55591798; -.
DR   KEGG; bms:BRA0061; -.
DR   KEGG; bsi:BS1330_II0061; -.
DR   PATRIC; fig|204722.21.peg.2309; -.
DR   HOGENOM; CLU_058585_3_0_5; -.
DR   OMA; MPAIYIE; -.
DR   PhylomeDB; Q9RPX6; -.
DR   PRO; PR:Q9RPX6; -.
DR   Proteomes; UP000007104; Chromosome II.
DR   CDD; cd06911; VirB9_CagX_TrbG; 1.
DR   Gene3D; 2.60.40.2500; -; 1.
DR   InterPro; IPR010258; Conjugal_tfr_TrbG/VirB9/CagX.
DR   InterPro; IPR014148; VirB9.
DR   InterPro; IPR033645; VirB9/CagX/TrbG_C.
DR   InterPro; IPR038161; VirB9/CagX/TrbG_C_sf.
DR   Pfam; PF03524; CagX; 1.
DR   TIGRFAMs; TIGR02781; VirB9; 1.
PE   2: Evidence at transcript level;
KW   Signal; Virulence.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..289
FT                   /note="Type IV secretion system protein virB9"
FT                   /id="PRO_0000291435"
SQ   SEQUENCE   289 AA;  31951 MW;  666BE65C328BD91C CRC64;
     MKRFLLACIL ITLASPSWAT KIPSGSKYDS RIQYVDYNSG DVVLVRALPG VGARIVFAPG
     ENIEDVASGF TQGWEFKASH NILYLKARSM TLSHSNQSID MAPEPGKWDT NLMVTTDQRM
     YDFDLRLMPG RNNQRVAYRV QFRYPAAAAA AAVAAAQKRV VQARMNARPS PVNWNYTMQV
     GTNSASIAPT LAYDDGRFTY LRFPNNRDFP AAFLVAEDKS ESIVNSHIDP SAPDILVLHR
     VAKQMVLRLG NKVIGIYNES FNPDGVPARD GTTVPGVKRV IKSPGENLQ
 
 
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