ID   VIRBA_BARQU             Reviewed;         385 AA.
AC   Q6FYW1; Q4L2Q3;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Type IV secretion system protein virB10;
GN   Name=virB10; OrderedLocusNames=BQ10610;
OS   Bartonella quintana (strain Toulouse) (Rochalimaea quintana).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=283165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Toulouse;
RA   Alsmark U.C.M., Frank A.C., Thollesson M., Andersson S.G.E.;
RT   "Evolution of type IV secretion systems in Bartonella: horizontal
RT   transmission and gene conversion.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND POSSIBLE FUNCTION.
RC   STRAIN=Toulouse;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT   of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC   -!- FUNCTION: Component of the type IV secretion system VirB/VirD4 which
CC       could be a major virulence determinant for subversion of human
CC       endothelial cell (HEC) function.
CC   -!- SUBUNIT: Interacts with virB4, virB8 and virB9. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TrbI/VirB10 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM82243.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY122055; AAM82243.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BX897700; CAF26528.1; -; Genomic_DNA.
DR   RefSeq; WP_011179732.1; NC_005955.1.
DR   AlphaFoldDB; Q6FYW1; -.
DR   SMR; Q6FYW1; -.
DR   STRING; 283165.BQ10610; -.
DR   EnsemblBacteria; CAF26528; CAF26528; BQ10610.
DR   KEGG; bqu:BQ10610; -.
DR   eggNOG; COG2948; Bacteria.
DR   HOGENOM; CLU_041899_1_0_5; -.
DR   OMA; NFIVAMG; -.
DR   OrthoDB; 552092at2; -.
DR   Proteomes; UP000000597; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd16429; VirB10; 1.
DR   Gene3D; 2.40.128.260; -; 2.
DR   InterPro; IPR005498; T4SS_VirB10/TraB/TrbI.
DR   InterPro; IPR042217; T4SS_VirB10/TrbI.
DR   Pfam; PF03743; TrbI; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..385
FT                   /note="Type IV secretion system protein virB10"
FT                   /id="PRO_0000281414"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          123..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..138
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   385 AA;  42512 MW;  A3766D3A0B8187D5 CRC64;
     MKDEIDENNI NDRSTIKDGQ GKKLHSNTSK AVALLVLLGV CGYLAYSTLI TNKKQPVELP
     KEAIIKQTER FRPAQPKPVL LEPTEKNNLL LPKVELPTPK RNQTNADDSL LEAAQRAPVL
     AYASPQKSQA NAEKNNDTSP NQLERKPDET AQRFNHLLKP TNLEGIHAST LTNRNYIIAM
     GASIPCILET AISSDQQGFT SCIVSRDILS DNGRVVLLDK GTQIVGEYRS GLKKGQNRLF
     VLWNRAKTPS GVIITLASPA TDALGRSGVD GDVDNHWFER IGSALLVSIV RDATNYARNR
     LPKDQDKNSS DTISSGPNIA NIVVENYANI PPTLTKNQGE MVNVFVARDL DFSSVYKLKV
     IEDKKQIVNR SISRNFYKNS AVILK