ID   VIRBA_BRUA2             Reviewed;         388 AA.
AC   Q2YJ81; Q57A23; Q9KIS6;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Type IV secretion system protein virB10;
GN   Name=virB10; OrderedLocusNames=BAB2_0059;
OS   Brucella abortus (strain 2308).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=359391;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, AND FUNCTION.
RX   PubMed=10940027; DOI=10.1128/jb.182.17.4849-4855.2000;
RA   Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.;
RT   "A homologue of an operon required for DNA transfer in Agrobacterium is
RT   required in Brucella abortus for virulence and intracellular
RT   multiplication.";
RL   J. Bacteriol. 182:4849-4855(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2308;
RX   PubMed=16299333; DOI=10.1128/iai.73.12.8353-8361.2005;
RA   Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A.,
RA   Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT   "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL   Infect. Immun. 73:8353-8361(2005).
CC   -!- FUNCTION: The virB operon is essential for intracellular survival and
CC       is not involved in the invasion process. Constitutes a major
CC       determinant of virulence in mice. Virb10 seems to be per se essential
CC       for intracellular multiplication within non-professional phagocytes and
CC       is essential for pathogenesis in mice. {ECO:0000269|PubMed:10940027}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Transcription is turned on at the beginning of the
CC       stationary phase of vegetative growth.
CC   -!- SIMILARITY: Belongs to the TrbI/VirB10 family. {ECO:0000305}.
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DR   EMBL; AF226278; AAF73903.1; -; Genomic_DNA.
DR   EMBL; AM040265; CAJ12225.1; -; Genomic_DNA.
DR   RefSeq; WP_002966519.1; NZ_KN046823.1.
DR   AlphaFoldDB; Q2YJ81; -.
DR   SMR; Q2YJ81; -.
DR   STRING; 359391.BAB2_0059; -.
DR   EnsemblBacteria; CAJ12225; CAJ12225; BAB2_0059.
DR   GeneID; 3827896; -.
DR   KEGG; bmf:BAB2_0059; -.
DR   PATRIC; fig|359391.11.peg.2007; -.
DR   HOGENOM; CLU_041899_6_0_5; -.
DR   OMA; PGKDRNT; -.
DR   PhylomeDB; Q2YJ81; -.
DR   BioCyc; MetaCyc:BAB_RS26640-MON; -.
DR   Proteomes; UP000002719; Chromosome II.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd16429; VirB10; 1.
DR   Gene3D; 2.40.128.260; -; 2.
DR   InterPro; IPR005498; T4SS_VirB10/TraB/TrbI.
DR   InterPro; IPR042217; T4SS_VirB10/TrbI.
DR   Pfam; PF03743; TrbI; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Virulence.
FT   CHAIN           1..388
FT                   /note="Type IV secretion system protein virB10"
FT                   /id="PRO_0000291384"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          79..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   388 AA;  41193 MW;  D8A63372B267E7F3 CRC64;
     MTQENIPVQP GTLDGERGLP TVNENGSGRT RKVLLFLFVV GFIVVLLLLL VFHMRGNAEN
     NHHSDKTMVQ TSTVPMRTFK LPPPPPPAPP EPPAPPPAPA MPIAEPAAAA LSLPPLPDDT
     PAKDDVLDKS ASALMVVTKS SGDTNAQTAG DTVVQTTNAR IQALLDSQKN TKQDAGSLGT
     LLHGTQTDAR MASLLRNRDF LLAKGSIINC ALQTRLDSTV PGMAACVVTR NMYSDNGKVL
     LIERGSTISG EYDANVKQGM ARIYVLWTRV KTPNGVVIDL DSPGADPLGG AGLPGYIDSH
     FWKRFGGALM LSTIETLGRY ATQKVGGGGS NQINLNTGGG ESTSNLASTA LKDTINIPPT
     LYKNQGEEIG IYIARDLDFS SVYDVKPK