ID   VIRBB_BARQU             Reviewed;         356 AA.
AC   Q6FYW0; Q4L2Q2; Q84BW3;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Type IV secretion system protein VirB11;
GN   Name=virB11; OrderedLocusNames=BQ10620;
OS   Bartonella quintana (strain Toulouse) (Rochalimaea quintana).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=283165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Toulouse;
RA   Alsmark U.C.M., Frank A.C., Thollesson M., Andersson S.G.E.;
RT   "Evolution of type IV secretion systems in Bartonella: horizontal
RT   transmission and gene conversion.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC VR-358 / Fuller / CIP 107027;
RA   Kohlhorst D.E., Soni T., Baumstark B.R.;
RT   "Genes composing the virB operon of Bartonella quintana.";
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND POSSIBLE FUNCTION.
RC   STRAIN=Toulouse;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT   of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC   -!- FUNCTION: Component of the type IV secretion system VirB/VirD4 which
CC       could be a major virulence determinant for subversion of human
CC       endothelial cell (HEC) function. Altogether with VirB4, may be
CC       implicated in providing the energy, via hydrolysis of ATP, for the
CC       assembly of secretion system and substrate transport.
CC   -!- SUBUNIT: Interacts with VirB9. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GSP E family. {ECO:0000305}.
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DR   EMBL; AY122055; AAM82244.1; -; Genomic_DNA.
DR   EMBL; AY216720; AAO85709.1; -; Genomic_DNA.
DR   EMBL; BX897700; CAF26529.1; -; Genomic_DNA.
DR   RefSeq; WP_011179733.1; NC_005955.1.
DR   AlphaFoldDB; Q6FYW0; -.
DR   SMR; Q6FYW0; -.
DR   STRING; 283165.BQ10620; -.
DR   EnsemblBacteria; CAF26529; CAF26529; BQ10620.
DR   KEGG; bqu:BQ10620; -.
DR   eggNOG; COG0630; Bacteria.
DR   HOGENOM; CLU_005379_3_1_5; -.
DR   OMA; GDEIVTM; -.
DR   OrthoDB; 473670at2; -.
DR   Proteomes; UP000000597; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043684; C:type IV secretion system complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0044097; P:secretion by the type IV secretion system; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001482; T2SS/T4SS.
DR   InterPro; IPR014155; VirB11.
DR   Pfam; PF00437; T2SSE; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02788; VirB11; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW   Nucleotide-binding; Transport; Virulence.
FT   CHAIN           1..356
FT                   /note="Type IV secretion system protein VirB11"
FT                   /id="PRO_0000281580"
FT   BINDING         187..194
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   VARIANT         39
FT                   /note="R -> S (in strain: ATCC VR-358 / Fuller / CIP
FT                   107027)"
FT   VARIANT         53
FT                   /note="T -> P (in strain: ATCC VR-358 / Fuller / CIP
FT                   107027)"
FT   VARIANT         195
FT                   /note="T -> P (in strain: ATCC VR-358 / Fuller / CIP
FT                   107027)"
FT   VARIANT         314
FT                   /note="Missing (in strain: ATCC VR-358 / Fuller / CIP
FT                   107027)"
FT   VARIANT         351..356
FT                   /note="NIFGGN -> HLEDLP (in strain: ATCC VR-358 / Fuller /
FT                   CIP 107027)"
SQ   SEQUENCE   356 AA;  39615 MW;  7D9A772095AFF039 CRC64;
     MNQNLHKLSN ETVAIVLTKL EPISAFLKDK SLFEIVINRP YQVMTEGIEG WKTIEAPALS
     FDELMGIAKV VASYSKQKIS DKNPILSATL PGNERIQIVI PPAVEKDTIS MTIRKPSSRN
     FSLEELANKG LFSVCEQVSF TPLNDYQSRF SELKHIEHSL ATAYSNKDFV SFLNQAVKCQ
     KNILIAGKTG SGKTTLSKAL IAKIPDNERI ITIEDTPELV VPQPNYVSMI YSKDGQGLAS
     VGPKELLESA LRMRPDRILL QELRDGTAFY YIRNINSGHP GSITTVHAST ALAAFEQMTL
     LVKESEGGGD LERDDIRGLL ISMIDIIVQC KRVEGKFKVT EIYYDPFKQR NIFGGN