VIRBB_BRUA2
ID VIRBB_BRUA2 Reviewed; 362 AA.
AC Q2YJ82; Q57A24; Q9KIS5;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Type IV secretion system protein VirB11;
GN Name=virB11; OrderedLocusNames=BAB2_0058;
OS Brucella abortus (strain 2308).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=359391;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, AND FUNCTION.
RX PubMed=10940027; DOI=10.1128/jb.182.17.4849-4855.2000;
RA Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.;
RT "A homologue of an operon required for DNA transfer in Agrobacterium is
RT required in Brucella abortus for virulence and intracellular
RT multiplication.";
RL J. Bacteriol. 182:4849-4855(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2308;
RX PubMed=16299333; DOI=10.1128/iai.73.12.8353-8361.2005;
RA Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A.,
RA Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL Infect. Immun. 73:8353-8361(2005).
CC -!- FUNCTION: The virB operon is essential for intracellular survival and
CC is not involved in the invasion process. Constitutes a major
CC determinant of virulence in mice. Virb11 is essential for pathogenesis
CC in mice but is not required for intracellular survival.
CC {ECO:0000269|PubMed:10940027}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- MISCELLANEOUS: Transcription is turned on at the beginning of the
CC stationary phase of vegetative growth.
CC -!- SIMILARITY: Belongs to the GSP E family. {ECO:0000305}.
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DR EMBL; AF226278; AAF73904.1; -; Genomic_DNA.
DR EMBL; AM040265; CAJ12224.1; -; Genomic_DNA.
DR AlphaFoldDB; Q2YJ82; -.
DR SMR; Q2YJ82; -.
DR STRING; 359391.BAB2_0058; -.
DR EnsemblBacteria; CAJ12224; CAJ12224; BAB2_0058.
DR KEGG; bmf:BAB2_0058; -.
DR PATRIC; fig|359391.11.peg.2006; -.
DR HOGENOM; CLU_005379_3_1_5; -.
DR OMA; GDEIVTM; -.
DR BioCyc; MetaCyc:BAB_RS26635-MON; -.
DR Proteomes; UP000002719; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043684; C:type IV secretion system complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0044097; P:secretion by the type IV secretion system; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR001482; T2SS/T4SS.
DR InterPro; IPR014155; VirB11.
DR Pfam; PF00437; T2SSE; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR02788; VirB11; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; Nucleotide-binding; Reference proteome; Virulence.
FT CHAIN 1..362
FT /note="Type IV secretion system protein VirB11"
FT /id="PRO_0000291436"
FT BINDING 182..189
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 362 AA; 40885 MW; 4C32B060F4FC79BD CRC64;
MMSNRSDFIV PDEAAVKRAA SVNFHLEPLR PWLDDPQITE VCVNRPGEVF CERASAWEYY
AVPNLDYEHL ISLGTATARF VDQDISDSRP VLSAILPMGE RIQIVRPPAC EHGTISVTIR
KPSFTRRTLE DYAQQGFFKH VRPMSKSLTP FEQELLALKE AGDYMSFLRR AVQLERVIVV
AGETGSGKTT LMKALMQEIP FDQRLITIED VPELFLPDHP NHVHLFYPSE AKEEENAPVT
AATLLRSCLR MKPTRILLAE LRGGETYDFI NVAASGHGGS ITSCHAGSCE LTFERLALMV
LQNRQGRQLP YEIIRRLLYL VVDVVVHVHN GVHDGTGRHI SEVWYDPNTK RALSLQHSEK
TQ