ID   VIRB_SHISO              Reviewed;         309 AA.
AC   P0A248; P11656;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Virulence regulon transcriptional activator VirB;
DE   AltName: Full=Cell invasion regulator InvE;
GN   Name=virB; Synonyms=invE;
OS   Shigella sonnei.
OG   Plasmid pINV.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=624;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=HW383;
RX   PubMed=1688841; DOI=10.1128/jb.172.2.619-629.1990;
RA   Watanabe H., Arakawa E., Ito K., Kato J., Nakamura A.;
RT   "Genetic analysis of an invasion region by use of a Tn3-lac transposon and
RT   identification of a second positive regulator gene, invE, for cell invasion
RT   of Shigella sonnei: significant homology of invE with ParB of plasmid P1.";
RL   J. Bacteriol. 172:619-629(1990).
CC   -!- FUNCTION: Transcription activator for the invasion antigens IpaB, IpaC
CC       and IpaD. VirB is itself regulated by VirF.
CC   -!- SIMILARITY: Belongs to the ParB family. {ECO:0000305}.
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DR   EMBL; M33790; AAA26520.1; -; Genomic_DNA.
DR   PIR; S69201; S69201.
DR   RefSeq; WP_000227976.1; NZ_UIQD01000016.1.
DR   AlphaFoldDB; P0A248; -.
DR   SMR; P0A248; -.
DR   STRING; 216599.GCA_000283715_05214; -.
DR   OMA; CIDANEG; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004437; ParB/RepB/Spo0J.
DR   InterPro; IPR003115; ParB/Sulfiredoxin_dom.
DR   InterPro; IPR036086; ParB/Sulfiredoxin_sf.
DR   InterPro; IPR014884; ParB_fam_C.
DR   Pfam; PF08775; ParB; 1.
DR   Pfam; PF02195; ParBc; 1.
DR   SMART; SM00470; ParB; 1.
DR   SUPFAM; SSF110849; SSF110849; 1.
DR   TIGRFAMs; TIGR00180; parB_part; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Plasmid; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..309
FT                   /note="Virulence regulon transcriptional activator VirB"
FT                   /id="PRO_0000178703"
FT   DNA_BIND        152..171
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   309 AA;  35408 MW;  AD5FEEBEBFF6C0C4 CRC64;
     MVDLCNDLLS IKEGQKKEFT LHSGNKVSFI KAKIPHKRIQ DLTFVNQKTN VRDQESLTEE
     SLADIIKTIK LQQFFPVIGR EIDGRIEILD GTRRRASAIY AGADLEVLYS KEYISTLDAR
     KLANDIQTAK EHSIRELGIG LNFLKVSGMS YKDIAKKENL SRAKVTRAFQ AASVPQEIIS
     LFPIASELNF NDYKILFNYY KGLEKANESL SSTLPILKEE IKDLDTNLPP DIYKKEILNI
     IKKSKNRKQN PSLKVDSLFI SKDKRTYIKR KENKTNRTLI FTLSKINKTV QREIDEAIRD
     IISRHLSSS