ID   VIRD2_AGRRH             Reviewed;         436 AA.
AC   P13462;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=T-DNA border endonuclease VirD2;
DE            EC=3.1.-.-;
GN   Name=virD2;
OS   Agrobacterium rhizogenes.
OG   Plasmid pRiA4b.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium.
OX   NCBI_TaxID=359;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A4;
RX   PubMed=3185501; DOI=10.1007/bf00339586;
RA   Hirayama T., Muranaka T., Ohkawa H., Oka A.;
RT   "Organization and characterization of the virCD genes from Agrobacterium
RT   rhizogenes.";
RL   Mol. Gen. Genet. 213:229-237(1988).
CC   -!- FUNCTION: Tumor formation by A.tumefaciens involves the transfer and
CC       integration of a defined segment (T-DNA) of Ti plasmid DNA into the
CC       plant nuclear genome. The virD operon encodes a site-specific
CC       endonuclease that cleaves at a unique site within both 24 bp direct
CC       repeats flanking the T-DNA.
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DR   EMBL; X12867; CAA31351.1; -; Genomic_DNA.
DR   PIR; S06884; S06884.
DR   RefSeq; WP_032488282.1; NZ_VCBD01000008.1.
DR   AlphaFoldDB; P13462; -.
DR   STRING; 359.CN09_19185; -.
DR   PRIDE; P13462; -.
DR   GeneID; 66389686; -.
DR   eggNOG; COG3843; Bacteria.
DR   GO; GO:0004520; F:endodeoxyribonuclease activity; IEA:InterPro.
DR   GO; GO:0051819; P:induction by symbiont of tumor or growth in host; IEA:InterPro.
DR   InterPro; IPR005094; Endonuclease_MobA/VirD2.
DR   InterPro; IPR016644; VirD2.
DR   Pfam; PF03432; Relaxase; 1.
DR   PIRSF; PIRSF016095; Endonuclease_VirD2; 1.
PE   4: Predicted;
KW   Crown gall tumor; Endonuclease; Hydrolase; Nuclease; Plasmid.
FT   CHAIN           1..436
FT                   /note="T-DNA border endonuclease VirD2"
FT                   /id="PRO_0000065858"
FT   REGION          213..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          290..436
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..236
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        246..261
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        308..323
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        324..341
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..436
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   436 AA;  48371 MW;  932A4365E0966AA6 CRC64;
     MPDRAQVIIR IVPGGGTKTL QQIINQLEYL SRKGKLELQR SARHLDIPLP PDQIHELARS
     WVQETGTYDE SQPDEERQQE LTTHIIVSFP AGTSQAAAYA ASREWAAEMF GSGAGGGSYN
     YLTAFHIDRD HPHLHVVVNR RELLGHGWLK ISRRHPQLNY DALRINMAEI SLRHGIVLDA
     SSRAERGIFE RPITYAQFRR LERQARQIRF EDADLEQSSS QGDHPEFSQS PDTAPFEASA
     GRSEGMPYPN NRQNGSQVHL HEPAGFSNRA GGSVRIALET QRLAIFADDI ESGSPPVSDV
     RAGNANADSD LPRSTVARTT DYSQRWSKRP RDDDEGPSGA KRVRLEGMAV GPEANAGERD
     SRGDPVAPPA ETSRPSSLQD MARPNTATDP LAASGHLEQR RGTLSKRPRV EDDGEPSERK
     RARDDRSQDG RGGNRR