CALA_EMENI
ID CALA_EMENI Reviewed; 171 AA.
AC Q5AVR1; A0A1U8QL78; C8VBW5;
DT 31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Secreted thaumatin-like protein calA {ECO:0000303|PubMed:16376592};
DE AltName: Full=CetA-like protein A {ECO:0000303|PubMed:16376592};
DE Flags: Precursor;
GN Name=calA {ECO:0000303|PubMed:16376592}; ORFNames=ANIA_07619;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
RN [3]
RP INDUCTION.
RX PubMed=16376592; DOI=10.1016/j.fgb.2005.10.001;
RA Greenstein S., Shadkchan Y., Jadoun J., Sharon C., Markovich S.,
RA Osherov N.;
RT "Analysis of the Aspergillus nidulans thaumatin-like cetA gene and evidence
RT for transcriptional repression of pyr4 expression in the cetA-disrupted
RT strain.";
RL Fungal Genet. Biol. 43:42-53(2006).
RN [4]
RP INDUCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=17703972; DOI=10.1016/j.fgb.2007.07.005;
RA Belaish R., Sharon H., Levdansky E., Greenstein S., Shadkchan Y.,
RA Osherov N.;
RT "The Aspergillus nidulans cetA and calA genes are involved in conidial
RT germination and cell wall morphogenesis.";
RL Fungal Genet. Biol. 45:232-242(2008).
CC -!- FUNCTION: Secreted thaumatin-like protein that, with cetA, plays an
CC essential role in early conidial germination with a possible role in
CC cell wall remodeling (PubMed:17703972). {ECO:0000269|PubMed:17703972}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17703972}. Secreted,
CC extracellular space, extracellular matrix
CC {ECO:0000269|PubMed:17703972}. Secreted, cell wall
CC {ECO:0000269|PubMed:17703972}. Note=Present in the cell walls of the
CC germinating conidia but not in the germtubes (PubMed:17703972).
CC {ECO:0000269|PubMed:17703972}.
CC -!- INDUCTION: Expression is inhibited by PKA activity but is not subject
CC to glucose repression (PubMed:16376592). Not expressed in dormant
CC conidia but only during germination (PubMed:16376592, PubMed:17703972).
CC {ECO:0000269|PubMed:16376592, ECO:0000269|PubMed:17703972}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype. The double deletion of cetA
CC and calA results in cell wall defects and lyse during germination,
CC leading to the inhibition of germination (PubMed:17703972).
CC {ECO:0000269|PubMed:17703972}.
CC -!- SIMILARITY: Belongs to the thaumatin family. {ECO:0000305}.
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DR EMBL; BN001304; CBF79755.1; -; Genomic_DNA.
DR EMBL; AACD01000130; EAA61805.1; -; Genomic_DNA.
DR RefSeq; XP_680888.1; XM_675796.1.
DR AlphaFoldDB; Q5AVR1; -.
DR SMR; Q5AVR1; -.
DR EnsemblFungi; CBF79755; CBF79755; ANIA_07619.
DR EnsemblFungi; EAA61805; EAA61805; AN7619.2.
DR GeneID; 2869581; -.
DR KEGG; ani:AN7619.2; -.
DR VEuPathDB; FungiDB:AN7619; -.
DR eggNOG; ENOG502SSWE; Eukaryota.
DR HOGENOM; CLU_083650_2_0_1; -.
DR InParanoid; Q5AVR1; -.
DR OMA; IDDASCP; -.
DR OrthoDB; 1403534at2759; -.
DR Proteomes; UP000000560; Chromosome IV.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0009847; P:spore germination; IMP:AspGD.
DR InterPro; IPR037176; Osmotin/thaumatin-like_sf.
DR SUPFAM; SSF49870; SSF49870; 1.
PE 2: Evidence at transcript level;
KW Cell wall; Disulfide bond; Extracellular matrix; Germination; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..171
FT /note="Secreted thaumatin-like protein calA"
FT /id="PRO_5010299494"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 141
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT DISULFID 130..157
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699"
FT DISULFID 135..142
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699"
SQ SEQUENCE 171 AA; 17868 MW; 775D2415D43A2F70 CRC64;
MLFNKIISLA ATLATASALP FAPAPRSISG GVTLINNLSQ DLYLWSVSGT ASPMVTLPAG
QSYQETWQIN PTGGGISIKI GCSEDGSDVL QYEYTKVGDL LFWDMSSIDL SSGSPLVAAG
FDVSIDDSSC DTVTCAPGDV NCSESYQYPD DHNTRACSSS AAYTLTLGTA N
