ID   VIRD4_BARQU             Reviewed;         639 AA.
AC   Q6FYV9;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Type IV secretion system-coupling protein VirD4;
GN   Name=virD4; Synonyms=traG; OrderedLocusNames=BQ10640;
OS   Bartonella quintana (strain Toulouse) (Rochalimaea quintana).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=283165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND POSSIBLE FUNCTION.
RC   STRAIN=Toulouse;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT   of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC   -!- FUNCTION: Component of the type IV secretion system VirB/VirD4 which
CC       could be a major virulence determinant for subversion of human
CC       endothelial cell (HEC) function.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the VirD4/TraG family. {ECO:0000305}.
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DR   EMBL; BX897700; CAF26531.1; -; Genomic_DNA.
DR   RefSeq; WP_011179734.1; NC_005955.1.
DR   AlphaFoldDB; Q6FYV9; -.
DR   STRING; 283165.BQ10640; -.
DR   EnsemblBacteria; CAF26531; CAF26531; BQ10640.
DR   KEGG; bqu:BQ10640; -.
DR   eggNOG; COG3505; Bacteria.
DR   HOGENOM; CLU_028732_0_0_5; -.
DR   OMA; SYFQNQA; -.
DR   OrthoDB; 246216at2; -.
DR   Proteomes; UP000000597; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014135; Ti-typ_conjug_TS_TraG-like.
DR   InterPro; IPR003688; TraG/VirD4.
DR   Pfam; PF02534; T4SS-DNA_transf; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02767; TraG-Ti; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport;
KW   Virulence.
FT   CHAIN           1..639
FT                   /note="Type IV secretion system-coupling protein VirD4"
FT                   /id="PRO_0000281581"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   639 AA;  71061 MW;  FE06E215D2A5AC63 CRC64;
     MKYTKIQLAL ILMPIALGAL TIFLVPHLLS FMINDLKANH VYWYVRSEPL LVLMLVATVS
     LCYTLSQKLH LRKAITLVSA VFFGITALYF IGGEIKRLTP YVGQQGITWS YALKFMDPMV
     VFGVICGVVL LVIQVMISSP PTSKVKRAKK GIFGDASWMN LKEAAKIFPA NGQIVVGERY
     RVDQDGVCNI PFAPGNKTTW GKGGTAPLLT FNLDFGSTHM IFFAGSGGYK TTSTVVPTCL
     TYPGPIVCLD PSTEIAPMVR FARKKMGNRN VIVLDPNSLL TKNFNVLDWL LDDSVPRTQR
     EANIVGFSKL LLTDKKSENS SAEYFSTQAH NLLTALLAHV IFSDEYEDSE RNLKTLRAIL
     SQSETAVVNQ LRMIQETTPS PFIREMVGIF TEMADQTFSG VYTTASKDTQ WLSLSNYADL
     VCGNDFSSSD IANGKTDVFL NLPASILNSY PAIGRVIIGA FLNAMVTADG KYKKRVLFVL
     DEVDLLGYMN ILEEARDRGR KYGTSLMLFY QSSGQLVNHF GEAGARSWFE SCSFVSYAAI
     KDLQTAKDIS ERCGQMTVEV TGTNKSRGLS LGKSSYNVNY QQRALILPHE IIQEMRQDEQ
     IILMQGQPPL RCGRAIYFRR KEMLAAANKN RFAPQAKKN