ID   VIRF_YERE8              Reviewed;         271 AA.
AC   A1JU91; P13225; Q93KT3;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Virulence regulon transcriptional activator VirF;
GN   Name=virF; OrderedLocusNames=YEP0035;
OS   Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS   8081).
OG   Plasmid pYVe8081.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=393305;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11402007; DOI=10.1128/iai.69.7.4627-4638.2001;
RA   Snellings N.J., Popek M., Lindler L.E.;
RT   "Complete DNA sequence of Yersinia enterocolitica serotype 0:8 low-calcium-
RT   response plasmid reveals a new virulence plasmid-associated replicon.";
RL   Infect. Immun. 69:4627-4638(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 13174 / 8081;
RX   PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA   Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA   Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA   Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA   Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA   Prentice M.B.;
RT   "The complete genome sequence and comparative genome analysis of the high
RT   pathogenicity Yersinia enterocolitica strain 8081.";
RL   PLoS Genet. 2:2039-2051(2006).
CC   -!- FUNCTION: Transcriptional activator of the Yersinia virulence regulon.
CC       {ECO:0000250}.
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DR   EMBL; AF336309; AAK69232.1; -; Genomic_DNA.
DR   EMBL; AM286416; CAL10057.1; -; Genomic_DNA.
DR   RefSeq; NP_783684.1; NC_004564.1.
DR   RefSeq; NP_863532.1; NC_005017.1.
DR   RefSeq; WP_005176447.1; NC_008791.1.
DR   RefSeq; YP_001004087.1; NC_008791.1.
DR   AlphaFoldDB; A1JU91; -.
DR   SMR; A1JU91; -.
DR   STRING; 393305.YEP0035; -.
DR   EnsemblBacteria; CAL10057; CAL10057; YEP0035.
DR   KEGG; yen:YEP0035; -.
DR   PATRIC; fig|393305.7.peg.36; -.
DR   eggNOG; COG2207; Bacteria.
DR   HOGENOM; CLU_073843_2_0_6; -.
DR   OMA; ISMEAGF; -.
DR   PRO; PR:A1JU91; -.
DR   Proteomes; UP000000642; Plasmid pYVe8081.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR037923; HTH-like.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF51215; SSF51215; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Plasmid; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..271
FT                   /note="Virulence regulon transcriptional activator VirF"
FT                   /id="PRO_0000285829"
FT   DOMAIN          167..265
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        184..205
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        232..255
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   271 AA;  30993 MW;  6E8FD317446370DE CRC64;
     MASLEIIKLE WATPIFKVVE HSQDGLYILL QGQVSWQNSS QTYDLDEGNM LFLRRGSYAV
     RCGTKEPCQL LWIPLPGSFL STFLHRFGSL LSEIRRDNST PKPLLIFNIS PILSQSIQNL
     CAILERSDFP SVLTQLRIEE LLLLLAFSSQ GTLFLSALRH LGNRPEERLQ KFMEENYLQG
     WKLSKFAREF GMGLTTFKEL FGTVYGISPR AWISERRILY AHQLLLNCKM SIVDIAMEAG
     FSSQSYFTQS YRRRFGCTPS QARLTKIATT G