ID   VIRF_YEREN              Reviewed;         271 AA.
AC   P0C2V5; P13225; Q93KT3;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Virulence regulon transcriptional activator VirF;
GN   Name=virF;
OS   Yersinia enterocolitica.
OG   Plasmid pYVe227, and Plasmid pYVa127/90.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=W22703 / Serotype O:9 / Biotype 2; PLASMID=pYVe227;
RX   PubMed=2644192; DOI=10.1128/jb.171.1.254-262.1989;
RA   Cornelis G., Sluiters C., de Rouvroit C.L., Michiels T.;
RT   "Homology between virF, the transcriptional activator of the Yersinia
RT   virulence regulon, and AraC, the Escherichia coli arabinose operon
RT   regulator.";
RL   J. Bacteriol. 171:254-262(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=W22703 / Serotype O:9 / Biotype 2; PLASMID=pYVe227;
RA   Iriarte M., Lambermont I., Kerbourch C., Cornelis G.R.;
RT   "Detailed genetic map of the pYVe227 plasmid of Yersinia enterocolitica
RT   serotype O:9.";
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A127/90 / Serotype O:8 / Biotype 1B; PLASMID=pYVa127/90;
RX   PubMed=14527656; DOI=10.1016/s0923-2508(03)00147-5;
RA   Foultier B., Cornelis G.R.;
RT   "DNA sequence and analysis of the pYVa127/90 virulence plasmid of Yersinia
RT   enterocolitica strain A127/90.";
RL   Res. Microbiol. 154:553-557(2003).
CC   -!- FUNCTION: Transcriptional activator of the Yersinia virulence regulon.
CC   -!- INDUCTION: By increase in temperature.
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DR   EMBL; AF102990; AAD16833.1; -; Genomic_DNA.
DR   EMBL; AY150843; AAN37560.1; -; Genomic_DNA.
DR   PIR; B32242; B32242.
DR   RefSeq; NP_052410.1; NC_002120.1.
DR   RefSeq; NP_783684.1; NC_004564.1.
DR   RefSeq; NP_863532.1; NC_005017.1.
DR   RefSeq; WP_005176447.1; NZ_NWMR01000033.1.
DR   RefSeq; WP_010891222.1; NZ_KN150737.1.
DR   AlphaFoldDB; P0C2V5; -.
DR   SMR; P0C2V5; -.
DR   PATRIC; fig|630.129.peg.4371; -.
DR   OrthoDB; 1268974at2; -.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR037923; HTH-like.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF51215; SSF51215; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Plasmid; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..271
FT                   /note="Virulence regulon transcriptional activator VirF"
FT                   /id="PRO_0000194596"
FT   DOMAIN          167..265
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        184..205
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        232..255
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   VARIANT         34
FT                   /note="I -> V (in plasmid pYVa127/90)"
FT   VARIANT         99
FT                   /note="A -> S (in plasmid pYVa127/90)"
FT   VARIANT         152
FT                   /note="A -> T (in plasmid pYVa127/90)"
FT   VARIANT         228
FT                   /note="G -> C (in plasmid pYVa127/90)"
SQ   SEQUENCE   271 AA;  30915 MW;  EB914144D2408F4A CRC64;
     MASLEIIKLE WATPIFKVVE HSQDGLYILL QGQISWQNSS QTYDLDEGNM LFLRRGSYAV
     RCGTKEPCQL LWIPLPGSFL STFLHRFGSL LSEIRRDNAT PKPLLIFNIS PILSQSIQNL
     CAILERSDFP SVLTQLRIEE LLLLLAFSSQ GALFLSALRH LGNRPEERLQ KFMEENYLQG
     WKLSKFAREF GMGLTTFKEL FGTVYGISPR AWISERRILY AHQLLLNGKM SIVDIAMEAG
     FSSQSYFTQS YRRRFGCTPS QARLTKIATT G